{"id":"W2329662932","doi":"10.1038/sj.gt.3301189","title":"A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle","year":2000,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":212,"is_retracted":false,"has_abstract":false,"ca_institutions":"Supratek Pharma (Canada)","funders":"","keywords":"Poloxamer; Plasmid; Gene expression; Molecular biology; Genetic enhancement; Gene; Biology; DNA; Reporter gene; Naked DNA; Chemistry; Biochemistry; Polymer; Copolymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008642488,0.00009258329,0.000135295,0.00005341961,0.00001511561,0.000002612234,0.0001325618,0.00008591443,0.0001852215],"category_scores_gemma":[0.000006710733,0.0000853168,0.00006793426,0.00007158518,0.00005919634,0.000004406802,0.00001877879,0.00003240037,0.000004092165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005564061,"about_ca_system_score_gemma":0.0000336365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001722911,"about_ca_topic_score_gemma":0.00001664943,"domain_scores_codex":[0.9993593,0.00005713692,0.0002050826,0.0001686195,0.00009136671,0.0001185135],"domain_scores_gemma":[0.9996466,0.000007139727,0.00007219811,0.0002052457,0.0000425468,0.00002628006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001910205,0.0002074049,0.001489386,0.000004395079,0.00001445327,8.931601e-7,0.00008232273,0.00008463196,0.9749365,0.000002121553,0.0001383262,0.0228485],"study_design_scores_gemma":[0.0009276692,0.0005987145,0.01658414,0.0000151164,0.000002470108,0.000002236064,0.00004205767,0.00001851821,0.9808184,0.00004577802,0.0008584631,0.00008642876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982951,0.00122855,0.00003274107,0.00002165611,0.0000286979,0.0001021917,0.00002272572,0.000003574866,0.0002647107],"genre_scores_gemma":[0.9963856,0.003032135,0.000228617,0.00008899468,0.00003423461,0.000009502451,0.00009556147,0.000009904982,0.0001154906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02276208,"threshold_uncertainty_score":0.3479118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009362644301803068,"score_gpt":0.2389617349712006,"score_spread":0.2295990906693975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}