{"id":"W2329678482","doi":"10.1021/ac102679r","title":"Surface Immobilization of Structure-Switching DNA Aptamers on Macroporous Sol−Gel-Derived Films for Solid-Phase Biosensing Applications","year":2011,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ontario Innovation Trust","keywords":"Aptamer; Chemistry; Biosensor; Biomolecule; Fluorescence; DNA; Specific surface area; Ethylene glycol; Combinatorial chemistry; Analyte; Molecule; Selectivity; Polyethylene glycol; Detection limit; Rolling circle replication; Nanotechnology; Fluorophore; Small molecule; Chromatography; Materials science; Biochemistry; Organic chemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001041217,0.0002242738,0.0002754439,0.00002667512,0.0001048144,0.00001369858,0.0001626376,0.0002472585,0.00001217476],"category_scores_gemma":[0.0001099145,0.0002045911,0.000195776,0.0001320492,0.0001709067,0.000004985027,0.00005390788,0.0001088058,7.236567e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000200184,"about_ca_system_score_gemma":0.00004697766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000092398,"about_ca_topic_score_gemma":0.00000457316,"domain_scores_codex":[0.9987251,0.00001705715,0.0003731477,0.0004862361,0.000135886,0.0002625472],"domain_scores_gemma":[0.9989774,0.00002649016,0.0002148438,0.0004682027,0.0002100087,0.0001030649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001624941,0.0001625329,0.00005238145,0.0000537835,0.000106236,0.000001218879,0.00002161648,0.00003354101,0.9976665,0.00003754743,0.0001437816,0.00155839],"study_design_scores_gemma":[0.0004305249,0.0001591075,0.00001584565,0.00002291359,0.000121148,0.000007765931,0.0001152408,0.002837085,0.995333,0.0002441939,0.0004709583,0.0002421989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947503,0.000035082,0.05138479,0.00003887049,0.0000166779,0.0002426657,0.0001090696,0.00004569214,0.0006241244],"genre_scores_gemma":[0.985027,0.00003261304,0.01414008,0.0001062846,0.00008481692,0.000006394484,0.0004236198,0.00002993438,0.0001492584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03752397,"threshold_uncertainty_score":0.8342982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913330630865646,"score_gpt":0.3242600547552951,"score_spread":0.3051267484466386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}