{"id":"W2329678482","doi":"10.1021/ac102679r","title":"Surface Immobilization of Structure-Switching DNA Aptamers on Macroporous Sol−Gel-Derived Films for Solid-Phase Biosensing Applications","year":2011,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ontario Innovation Trust","keywords":"Aptamer; Chemistry; Biosensor; Biomolecule; Fluorescence; DNA; Specific surface area; Ethylene glycol; Combinatorial chemistry; Analyte; Molecule; Selectivity; Polyethylene glycol; Detection limit; Rolling circle replication; Nanotechnology; Fluorophore; Small molecule; Chromatography; Materials science; Biochemistry; Organic chemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108012,0.00033734,0.0001671823,0.0001526479,0.00009846105,0.0002046522,0.0001520362,0.0002724441,0.0004010847],"category_scores_gemma":[0.0001309385,0.000209383,0.0001749,0.00009368504,0.0001334395,0.0001639825,0.0001354314,0.0003027372,0.0002198926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002016661,"about_ca_system_score_gemma":0.000130381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000253532,"about_ca_topic_score_gemma":0.0005574605,"domain_scores_codex":[0.9999192,0.000009471246,0.000005584535,0.00002018782,0.0000307172,0.00001477333],"domain_scores_gemma":[0.9999337,0.00002243768,0.00001512271,0.000005100023,0.0000119559,0.00001167396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004557678,0.000002887691,0.00001803671,0.000009004551,0.000001113586,0.000006828469,0.000003113988,0.000024906,0.9995492,0.00001032657,0.000006044187,0.0003640956],"study_design_scores_gemma":[0.000002728303,0.00004047167,0.0004767679,0.000001225254,0.000003619927,0.00002709922,0.000005014605,0.0006500188,0.998477,0.000008127998,0.0003065946,0.000001390837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835157,0.00100865,0.01366192,0.00009666676,0.00003881973,0.00006562919,0.0001223169,0.0001788078,0.001311525],"genre_scores_gemma":[0.9765874,0.001012319,0.02051316,0.00007885313,0.00001967688,0.00004823368,0.0002041545,0.0000351875,0.001501043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004010847,"threshold_uncertainty_score":0.001463234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01913330630865646,"score_gpt":0.3242600547552951,"score_spread":0.3051267484466386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}