{"id":"W2329751573","doi":"10.1021/acsmedchemlett.6b00064","title":"Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus","year":2016,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Metabolic stability; Human cytomegalovirus; Pharmacokinetics; Viral replication; Potency; Viral life cycle; Drug discovery; Cytomegalovirus; Pharmacology; High-throughput screening; Chemistry; Mechanism of action; Virus; Biochemistry; Virology; Biology; In vitro; Herpesviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673215,0.0007157831,0.0004655027,0.0005841358,0.0001639362,0.0003932712,0.0004360084,0.0003097004,0.002391505],"category_scores_gemma":[0.0001727958,0.0002546704,0.0002608404,0.0003253139,0.0001492344,0.0002912451,0.000277437,0.0006259475,0.0006097851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074328,"about_ca_system_score_gemma":0.0002896652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005290618,"about_ca_topic_score_gemma":0.002548146,"domain_scores_codex":[0.9999306,0.000009108512,0.000003599874,0.00001414286,0.00001646662,0.00002606863],"domain_scores_gemma":[0.9999524,0.00001136394,0.000009800873,0.00000370016,0.000008624168,0.00001419232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004743781,0.0008906693,0.0006670735,0.0005194252,0.00007420959,0.0007445579,0.0001430305,0.002741156,0.929924,0.001215936,0.001730313,0.06087534],"study_design_scores_gemma":[0.001140191,0.01605566,0.007659194,0.0001655155,0.0002812143,0.001672954,0.0001144046,0.005100633,0.932028,0.0006413138,0.03506982,0.00007112443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9362047,0.02362781,0.01845346,0.0005779098,0.0001515685,0.001143887,0.003249018,0.0004888492,0.01610278],"genre_scores_gemma":[0.9609221,0.01738047,0.009009521,0.000331454,0.0000616875,0.0003311649,0.001952728,0.00003933493,0.009971412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002391505,"threshold_uncertainty_score":0.008000433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211264317707776,"score_gpt":0.2880632272835279,"score_spread":0.2669367955127503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}