{"id":"W2329751573","doi":"10.1021/acsmedchemlett.6b00064","title":"Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus","year":2016,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Boehringer Ingelheim","keywords":"Metabolic stability; Human cytomegalovirus; Pharmacokinetics; Viral replication; Potency; Viral life cycle; Drug discovery; Cytomegalovirus; Pharmacology; High-throughput screening; Chemistry; Mechanism of action; Virus; Biochemistry; Virology; Biology; In vitro; Herpesviridae; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004116004,0.0002555597,0.0006577607,0.000149352,0.00005772546,0.000011568,0.0002887584,0.0001535781,0.0003597789],"category_scores_gemma":[0.0001727064,0.0001684643,0.0002022821,0.0003510911,0.0008293524,0.0001955328,0.0001257244,0.0002828162,0.0000336459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598464,"about_ca_system_score_gemma":0.000199202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003841181,"about_ca_topic_score_gemma":0.000006379144,"domain_scores_codex":[0.997456,0.00002803365,0.0006912493,0.0003989166,0.0009438866,0.0004819307],"domain_scores_gemma":[0.9985748,0.0001245771,0.0002821775,0.0006147866,0.0001798265,0.0002238296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004293416,0.0001709002,0.01656995,0.0006310957,0.0001379915,0.0001273958,0.00008834653,2.131138e-7,0.9695325,0.00002127232,0.009459601,0.002831393],"study_design_scores_gemma":[0.002643291,0.0002165703,0.003851089,0.0008382245,0.0001014798,0.00006411639,0.0001152378,8.763241e-7,0.988899,0.00002557435,0.003063454,0.0001810776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898894,0.0002919344,0.00006186072,0.004534291,0.00007165694,0.0002068575,0.00005263629,0.00003334932,0.004857972],"genre_scores_gemma":[0.9962725,0.0001226147,0.00007313114,0.0004866655,0.0004074096,0.00001147489,0.00002326246,0.00003965014,0.002563294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0193665,"threshold_uncertainty_score":0.6869776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0211264317707776,"score_gpt":0.2880632272835279,"score_spread":0.2669367955127503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}