{"id":"W2329849388","doi":"10.1021/bi501438p","title":"Mechanistic Evaluation of a Nucleoside Tetraphosphate with a Thymidylyltransferase","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nucleoside; Chemistry; Substrate (aquarium); Mass spectrometry; Nuclear magnetic resonance spectroscopy; Pyrimidine; Polyphosphate; Enzyme; Biochemistry; Liquid chromatography–mass spectrometry; Pyrimidine metabolism; Tandem mass spectrometry; Stereochemistry; Purine; Chromatography; Phosphate; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004883902,0.0001613468,0.0001381378,0.00002517084,0.00002747886,0.00001376195,0.0002142997,0.0001652093,0.00003082128],"category_scores_gemma":[0.000221697,0.0001355743,0.00007055281,0.0001490465,0.0001457539,0.000002450064,0.00006174708,0.0000923927,0.000005919207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002830358,"about_ca_system_score_gemma":0.000466397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002604219,"about_ca_topic_score_gemma":0.000005439139,"domain_scores_codex":[0.9985393,0.00004953089,0.000176288,0.0003636085,0.0006317385,0.000239504],"domain_scores_gemma":[0.9987487,0.000005778538,0.00005418999,0.0004208907,0.0005471055,0.0002233196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000300506,0.000110277,0.000222536,0.00004692446,0.00006033073,0.000004168447,0.00001653451,0.00001609361,0.9962702,0.00003444995,0.0007979001,0.002120095],"study_design_scores_gemma":[0.001463209,0.0002956513,0.0000611378,0.00003148774,0.00006758262,0.0000310901,0.00009068169,0.0002110504,0.9967455,0.0001440399,0.000674188,0.0001844218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933282,0.001552185,0.0009811522,0.0000799939,0.00003003313,0.0002265248,0.00002842719,0.00001310199,0.003760342],"genre_scores_gemma":[0.9986696,0.00002730173,0.0007170649,0.00006963102,0.00007514021,0.00004693121,0.0001631732,0.00002451566,0.0002066523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005341351,"threshold_uncertainty_score":0.5528561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03587962329467644,"score_gpt":0.2914530278176081,"score_spread":0.2555734045229316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}