{"id":"W2329849388","doi":"10.1021/bi501438p","title":"Mechanistic Evaluation of a Nucleoside Tetraphosphate with a Thymidylyltransferase","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nucleoside; Chemistry; Substrate (aquarium); Mass spectrometry; Nuclear magnetic resonance spectroscopy; Pyrimidine; Polyphosphate; Enzyme; Biochemistry; Liquid chromatography–mass spectrometry; Pyrimidine metabolism; Tandem mass spectrometry; Stereochemistry; Purine; Chromatography; Phosphate; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006860001,0.0007231623,0.0003650159,0.0001752386,0.0002036713,0.0005734846,0.0003452703,0.0006610659,0.0006112061],"category_scores_gemma":[0.00060775,0.0002036416,0.0003461061,0.0002234805,0.0003316196,0.0006661973,0.0005302451,0.0006257279,0.0003563401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005736582,"about_ca_system_score_gemma":0.0004945507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004720654,"about_ca_topic_score_gemma":0.0004647136,"domain_scores_codex":[0.9995165,0.0001278552,0.00004963504,0.000097875,0.0001338976,0.00007418649],"domain_scores_gemma":[0.9997622,0.00004537598,0.00005325407,0.00003149012,0.00005525519,0.00005236488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001402072,0.00004976863,0.0003397237,0.00008601906,0.00001326591,0.0001895657,0.00002754436,0.0004647923,0.9959925,0.0003443195,0.00002428918,0.002327966],"study_design_scores_gemma":[0.000007688683,0.000287492,0.0001700995,0.000002476819,0.00001043909,0.00009029841,0.000008796492,0.0007571168,0.9976888,0.00003987732,0.0009332632,0.000003579244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813623,0.00130171,0.01399368,0.0001485541,0.00003971836,0.0001369366,0.0002559095,0.00008824997,0.002672802],"genre_scores_gemma":[0.9881874,0.0006622285,0.009740403,0.00003816976,0.000008323747,0.00004595471,0.0002265035,0.00002287295,0.001068126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007231623,"threshold_uncertainty_score":0.004162252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03587962329467644,"score_gpt":0.2914530278176081,"score_spread":0.2555734045229316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}