{"id":"W2329859787","doi":"10.1021/acs.biochem.6b00132","title":"<i>In Vitro</i> Selection of a DNAzyme Cooperatively Binding Two Lanthanide Ions for RNA Cleavage","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Lanthanide; Chemistry; Cleavage (geology); Nucleotide; Stereochemistry; Diastereomer; Metal ions in aqueous solution; DNA; RNA; Ion; Crystallography; Biochemistry; Materials science; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000397063,0.0006327623,0.0005035141,0.000160383,0.00009654965,0.0004810498,0.0004258507,0.000408553,0.0006307966],"category_scores_gemma":[0.0003474788,0.0002885696,0.0004227821,0.0002096199,0.0002093676,0.0001869828,0.0003883096,0.0004974175,0.0007967417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771087,"about_ca_system_score_gemma":0.0001719425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003070936,"about_ca_topic_score_gemma":0.0004509094,"domain_scores_codex":[0.999503,0.0001366403,0.00005084874,0.0001245214,0.0001026443,0.00008235969],"domain_scores_gemma":[0.9997191,0.00005523616,0.0000820737,0.00004535489,0.00004414613,0.00005404983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001565614,0.00000734497,0.00007153587,0.00001383308,0.000002759904,0.000009187572,0.000003867251,0.00003329748,0.9993101,0.00001668114,0.000009679729,0.0005061145],"study_design_scores_gemma":[0.000002939187,0.00007080205,0.0002159331,0.000001119078,0.000004168003,0.00005152388,0.000003787576,0.0003447235,0.9988081,0.000005438092,0.0004897654,0.000001637255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478925,0.001942012,0.04713365,0.0001175025,0.00006996876,0.0001674586,0.0003078667,0.0003115188,0.002057576],"genre_scores_gemma":[0.9433225,0.001068786,0.04683821,0.0001048046,0.00001911299,0.000186019,0.00118564,0.000134135,0.00714071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006327623,"threshold_uncertainty_score":0.002110243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009535243147519636,"score_gpt":0.2829102316420496,"score_spread":0.27337498849453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}