{"id":"W2330047397","doi":"10.1097/01.prs.0000455489.32830.4a","title":"A Pooled Analysis of the Safety and Efficacy Results of the Multicenter, Double-Blind, Randomized, Placebo-Controlled Phase 3 REFINE-1 and REFINE-2 Trials of ATX-101, a Submental Contouring Injectable Drug for the Reduction of Submental Fat","year":2014,"lang":"en","type":"article","venue":"Plastic & Reconstructive Surgery","topic":"Body Contouring and Surgery","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Adverse effect; Clinical endpoint; Randomized controlled trial; Internal medicine; Magnetic resonance imaging; Contouring; Clinical trial; Phases of clinical research; Multicenter study; Nuclear medicine; Urology; Surgery; Gastroenterology; Radiology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02140467,0.002766073,0.009520071,0.00206051,0.0003828722,0.001826886,0.0009331719,0.001997748,0.003860469],"category_scores_gemma":[0.02521048,0.001050756,0.01453442,0.001758393,0.0007348217,0.001121416,0.0009222808,0.001336914,0.0004429167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001012327,"about_ca_system_score_gemma":0.001115102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007969125,"about_ca_topic_score_gemma":0.001415211,"domain_scores_codex":[0.9831888,0.01212006,0.001884774,0.001448467,0.001003978,0.0003538782],"domain_scores_gemma":[0.9833098,0.008569654,0.00497986,0.001262783,0.001439056,0.0004387803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.6440036,0.0006135681,0.005856213,0.01471235,0.3078599,0.0001020413,0.00007148143,0.001234218,0.002672205,0.0001179976,0.001481191,0.02127521],"study_design_scores_gemma":[0.3993893,0.04555203,0.03054485,0.0009481116,0.5167863,0.0002388392,0.00009741424,0.001907306,0.001448594,0.0004527706,0.002510545,0.0001239137],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6113123,0.3442514,0.01222707,0.001190059,0.001918324,0.009324056,0.01460694,0.0005944397,0.00457543],"genre_scores_gemma":[0.9663574,0.01801211,0.004259907,0.0008126899,0.000680983,0.004969464,0.00390393,0.00005715542,0.0009465222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02140467,"threshold_uncertainty_score":0.1132001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886867242803724,"score_gpt":0.2885842606714316,"score_spread":0.2597155882433943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}