{"id":"W2330047397","doi":"10.1097/01.prs.0000455489.32830.4a","title":"A Pooled Analysis of the Safety and Efficacy Results of the Multicenter, Double-Blind, Randomized, Placebo-Controlled Phase 3 REFINE-1 and REFINE-2 Trials of ATX-101, a Submental Contouring Injectable Drug for the Reduction of Submental Fat","year":2014,"lang":"en","type":"article","venue":"Plastic & Reconstructive Surgery","topic":"Body Contouring and Surgery","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Placebo; Adverse effect; Clinical endpoint; Randomized controlled trial; Internal medicine; Magnetic resonance imaging; Contouring; Clinical trial; Phases of clinical research; Multicenter study; Nuclear medicine; Urology; Surgery; Gastroenterology; Radiology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.008602717,0.0003141292,0.003610867,0.0004570004,0.0001800936,0.00001660261,0.0001345436,0.0001173054,0.00001512087],"category_scores_gemma":[0.01561502,0.0001608967,0.00146963,0.0005579013,0.001117001,0.00009733847,0.00009611071,0.0002225138,7.434482e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006612282,"about_ca_system_score_gemma":0.0001585813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005592423,"about_ca_topic_score_gemma":0.00009198382,"domain_scores_codex":[0.9949504,0.001242528,0.00265647,0.0004175443,0.000428816,0.0003042212],"domain_scores_gemma":[0.9571927,0.03902613,0.002835204,0.0005037942,0.0003560573,0.0000860937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9529542,0.0004029611,0.01028805,0.000260894,0.00868539,5.814596e-7,0.001042875,0.0001120739,0.01891437,0.0001039912,0.000090173,0.007144394],"study_design_scores_gemma":[0.8832819,0.0001482381,0.007099135,0.001191407,0.0197481,0.00003355119,0.001762783,0.0077515,0.07866106,0.0000292442,0.00004585962,0.0002472118],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942325,0.0008950644,0.0002055584,0.0002201359,0.001010249,0.002966381,0.000333626,0.00001179957,0.0001246745],"genre_scores_gemma":[0.9991827,0.0002194491,0.000103241,0.000009420723,0.0001861461,0.0001282568,0.00002964062,0.00002144302,0.0001196836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06967235,"threshold_uncertainty_score":0.9926769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02886867242803724,"score_gpt":0.2885842606714316,"score_spread":0.2597155882433943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}