{"id":"W2330054261","doi":"10.1089/ten.tea.2013.0160","title":"Superficial Dermal Fibroblasts Enhance Basement Membrane and Epidermal Barrier Formation in Tissue-Engineered Skin: Implications for Treatment of Skin Basement Membrane Disorders","year":2013,"lang":"en","type":"article","venue":"Tissue Engineering Part A","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Dermis; Basement membrane; Dermoepidermal junction; Epidermis (zoology); Perlecan; Barrier function; Keratinocyte; Wound healing; Hemidesmosome; Fibroblast; Skin equivalent; Lamina densa; Dermal fibroblast; Chemistry; Cell biology; Human skin; Pathology; Extracellular matrix; Biology; Anatomy; Medicine; Immunology; Biochemistry; In vitro; Proteoglycan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002806877,0.0004492362,0.0002365259,0.0002418945,0.0001029589,0.0003883237,0.000207688,0.0004246568,0.0008128877],"category_scores_gemma":[0.0001117938,0.00008763995,0.0003172613,0.0001356046,0.0001331828,0.0003992755,0.0001834528,0.0004980433,0.0001718022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001458549,"about_ca_system_score_gemma":0.0001204014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002222491,"about_ca_topic_score_gemma":0.0003725471,"domain_scores_codex":[0.9998848,0.00002715065,0.000008689273,0.0000164042,0.0000433956,0.00001949351],"domain_scores_gemma":[0.9999349,0.00001113757,0.00001692039,0.000005341421,0.00001482474,0.00001692544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001466867,0.0002191014,0.0003165325,0.0003251734,0.00002207763,0.0001981524,0.00004100305,0.0002121454,0.973604,0.0005939729,0.0002496919,0.02407142],"study_design_scores_gemma":[0.0001276577,0.001861618,0.006433932,0.0001474684,0.0001928949,0.001502679,0.0001428017,0.002275974,0.9603726,0.0006732791,0.02624624,0.00002280947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8138753,0.1387202,0.0363159,0.002242505,0.0007712331,0.0002466587,0.0003105825,0.0002959823,0.007221591],"genre_scores_gemma":[0.9560241,0.02686202,0.01387684,0.0004420542,0.00009993603,0.00007569741,0.0001357867,0.00002111206,0.002462617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008128877,"threshold_uncertainty_score":0.002719402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008769405769654171,"score_gpt":0.2597755336861015,"score_spread":0.2510061279164473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}