{"id":"W2330054261","doi":"10.1089/ten.tea.2013.0160","title":"Superficial Dermal Fibroblasts Enhance Basement Membrane and Epidermal Barrier Formation in Tissue-Engineered Skin: Implications for Treatment of Skin Basement Membrane Disorders","year":2013,"lang":"en","type":"article","venue":"Tissue Engineering Part A","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta","keywords":"Dermis; Basement membrane; Dermoepidermal junction; Epidermis (zoology); Perlecan; Barrier function; Keratinocyte; Wound healing; Hemidesmosome; Fibroblast; Skin equivalent; Lamina densa; Dermal fibroblast; Chemistry; Cell biology; Human skin; Pathology; Extracellular matrix; Biology; Anatomy; Medicine; Immunology; Biochemistry; In vitro; Proteoglycan","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174312,0.0002046597,0.0002327603,0.00009589021,0.00004993968,0.00001546602,0.0001020324,0.0001301222,0.00009621378],"category_scores_gemma":[0.00004366347,0.0002006947,0.00005523922,0.00009128232,0.00003959025,0.00001564117,0.00004174614,0.00004091774,0.000007841288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003269583,"about_ca_system_score_gemma":0.0000250648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000108079,"about_ca_topic_score_gemma":0.0001349131,"domain_scores_codex":[0.9989046,0.00003310587,0.0003204217,0.0002965103,0.00008073062,0.0003646735],"domain_scores_gemma":[0.9995029,0.0000461149,0.00004290258,0.000255032,0.00004837551,0.0001046567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003642814,0.0001139209,0.0002490733,0.000127469,0.0000444624,9.140001e-7,0.0001431872,0.00230752,0.9863309,0.00006136188,0.0002008986,0.01038386],"study_design_scores_gemma":[0.0009136522,0.0005335359,0.003173741,0.00002430534,0.00001530774,0.00001338333,0.00003709223,0.003205297,0.9635392,0.000007229854,0.02833554,0.0002017141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793536,0.001247425,0.01766236,0.0003617436,0.00008435209,0.001149805,0.00006866334,0.00001546634,0.00005655303],"genre_scores_gemma":[0.9962248,0.0005004684,0.001485199,0.00001236707,0.0001358749,0.0007736519,0.0004945863,0.00002684479,0.0003461906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02813464,"threshold_uncertainty_score":0.818409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008769405769654171,"score_gpt":0.2597755336861015,"score_spread":0.2510061279164473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}