{"id":"W2330105594","doi":"10.3748/wjg.v22.i9.2779","title":"New role and molecular mechanism of Gadd45a in hepatic ﬁbrosis","year":2016,"lang":"en","type":"article","venue":"World Journal of Gastroenterology","topic":"Liver physiology and pathology","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"Chinese Academy of Sciences","keywords":"SMAD; Hepatic stellate cell; Small interfering RNA; Smad2 Protein; Liver injury; Molecular biology; Type I collagen; Gene knockdown; Biology; Reactive oxygen species; Signal transduction; Chemistry; Cell biology; Cancer research; Apoptosis; Biochemistry; Endocrinology; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002164305,0.00009130599,0.0004753247,0.0003281021,0.000008343063,9.398036e-7,0.00008136631,0.00005752568,0.0001767859],"category_scores_gemma":[0.00003987885,0.00005980898,0.00008023498,0.00006509935,0.0001001579,0.00004607326,0.00004235741,0.0001656949,0.000003277511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002012479,"about_ca_system_score_gemma":0.00004029878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000117548,"about_ca_topic_score_gemma":0.00007228852,"domain_scores_codex":[0.9990647,0.0001571147,0.0003933305,0.0001066471,0.00007732267,0.0002008365],"domain_scores_gemma":[0.9994036,0.00006438625,0.0002511568,0.000113263,0.00005626892,0.0001113336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002839124,0.00009632257,0.5117913,0.00002073405,0.0000985369,0.0002803522,0.0001433666,0.000001041195,0.4813351,0.001069183,0.0001941879,0.002130778],"study_design_scores_gemma":[0.01256178,0.01114324,0.908558,0.0005175385,0.0002839906,0.003542315,0.00006578694,0.00001787634,0.03924021,0.02366393,0.00030827,0.0000970601],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940726,0.0002575594,0.002646967,0.002732261,0.0001306459,0.00006052712,0.000001653672,0.000002616742,0.00009516718],"genre_scores_gemma":[0.9961316,0.0001191761,0.002672517,0.000907201,0.00006080579,9.152859e-7,3.80103e-7,0.000007836196,0.00009958474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4420949,"threshold_uncertainty_score":0.2438939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006027309718075161,"score_gpt":0.2264943114475152,"score_spread":0.22046700172944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}