{"id":"W2330366970","doi":"10.1055/s-0031-1277077","title":"FAM131B-BRAF Fusion Gene Resulting From 7q34 Deletion Leads to MAPK Pathway Activation in Pilocytic Astrocytoma","year":2011,"lang":"en","type":"article","venue":"Klinische Pädiatrie","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Pilocytic astrocytoma; Neurofibromatosis; Gene duplication; Medicine; KRAS; Cancer research; MAPK/ERK pathway; Astrocytoma; Neurofibromatosis type I; Fusion gene; Gene; Mutation; Pathology; Glioma; Biology; Genetics; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003057796,0.0002621566,0.0003914866,0.0002997069,0.00009714656,0.00002585988,0.00010785,0.000193984,0.0001950161],"category_scores_gemma":[0.0003123565,0.0002323879,0.000117988,0.0004345658,0.00002186189,0.0001451982,0.00008886238,0.0002454011,0.0004012109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002055335,"about_ca_system_score_gemma":0.0001346632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009476577,"about_ca_topic_score_gemma":0.0001525609,"domain_scores_codex":[0.9980749,0.00008565877,0.0005445628,0.0005364647,0.0003557393,0.0004026277],"domain_scores_gemma":[0.9988843,0.0001539238,0.0001697005,0.0004386593,0.0001075716,0.0002458668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003179081,0.00203032,0.4041766,0.00005702677,0.0001161731,0.0004555907,0.00313456,0.00006407413,0.5504141,0.000253556,0.001096436,0.03502246],"study_design_scores_gemma":[0.004766757,0.0009070995,0.3621381,0.0001652192,0.000101189,0.000008364865,0.0001955057,0.0001523647,0.630293,0.000105402,0.0009378425,0.0002291414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961627,0.0001586095,0.0006563231,0.0006747713,0.0001808938,0.0007292557,0.00002887653,0.0001038821,0.001304701],"genre_scores_gemma":[0.9862147,0.00003859241,0.01239657,0.0004968592,0.0003980258,0.0001203281,0.0002343139,0.00004347312,0.00005716568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0798789,"threshold_uncertainty_score":0.9476504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04227801597901934,"score_gpt":0.2629772653891458,"score_spread":0.2206992494101264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}