{"id":"W2330409402","doi":"10.1152/physiolgenomics.00166.2013","title":"Contractile abnormalities of mouse muscles expressing hyperkalemic periodic paralysis mutant NaV1.4 channels do not correlate with Na<sup>+</sup>influx or channel content","year":2014,"lang":"en","type":"article","venue":"Physiological Genomics","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Tetrodotoxin; Myosin; Gene isoform; Internal medicine; NAV1; Contractility; Endocrinology; Biology; Sodium channel; Mutant; Phenotype; Diaphragm (acoustics); Myotonia; Chemistry; Cell biology; Biochemistry; Sodium; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002095606,0.0004726039,0.0002317903,0.0006802071,0.0001730565,0.0002883867,0.0002748401,0.000541239,0.001540658],"category_scores_gemma":[0.0001552079,0.0003205026,0.0003598162,0.0002580376,0.0003790449,0.0002737091,0.0002750399,0.0005824335,0.0004076537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00032329,"about_ca_system_score_gemma":0.0001310634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005770043,"about_ca_topic_score_gemma":0.001075184,"domain_scores_codex":[0.9996547,0.00003679474,0.00005022639,0.0001078507,0.00007822447,0.00007241711],"domain_scores_gemma":[0.9994695,0.00006923451,0.0002167427,0.00004558386,0.00005014903,0.0001488854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006821656,0.00001518424,0.000433727,0.0000143049,0.000005393808,0.00004007472,0.00001233279,0.00001611865,0.9991504,0.00002444899,0.000009588965,0.0002101813],"study_design_scores_gemma":[0.0000308029,0.0006527051,0.06987775,0.00001851776,0.00004036173,0.0009947829,0.00009383078,0.0007047961,0.9266462,0.00007723169,0.0008499733,0.00001307116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960376,0.0006161351,0.001592953,0.00005384689,0.00001547528,0.00002300828,0.0008835947,0.00007611371,0.0007013303],"genre_scores_gemma":[0.9887616,0.0006000702,0.003417714,0.0001063028,0.00001000541,0.0001385361,0.002335262,0.00006885126,0.004561717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001540658,"threshold_uncertainty_score":0.005154014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03742834415830078,"score_gpt":0.2330892820214929,"score_spread":0.1956609378631922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}