{"id":"W2330446781","doi":"10.1021/np100657w","title":"Human Cytochrome P450 Liability Studies of <i>trans</i>-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer Cell Growth Inhibitor","year":2010,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Windsor","funders":"","keywords":"Amaryllidaceae Alkaloids; Alkaloid; Stereochemistry; CYP3A4; Chemistry; Enzyme; Cytochrome P450; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004029824,0.0002495682,0.0005990035,0.00004613468,0.000111211,0.00002623541,0.0002425212,0.0001442978,0.0001501644],"category_scores_gemma":[0.0006777295,0.0001794378,0.0001382281,0.0001952434,0.000316488,0.0003311936,0.00007447516,0.0009988508,0.000001111598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001307804,"about_ca_system_score_gemma":0.0001237959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001020564,"about_ca_topic_score_gemma":0.00004636981,"domain_scores_codex":[0.9982916,0.00002962067,0.0006471308,0.0003493811,0.0004013273,0.0002809917],"domain_scores_gemma":[0.9978117,0.000130592,0.0005717062,0.0002308595,0.001134566,0.0001205633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001317063,0.0002391586,0.001338239,0.0007600498,0.000137406,0.00001017727,0.0002882931,4.252313e-7,0.9908814,0.000008085276,0.005578229,0.0006267807],"study_design_scores_gemma":[0.0007009599,0.00009590748,0.003266169,0.0001942834,0.000123618,0.00007375561,0.00008757076,0.00000276989,0.9931821,0.0003785677,0.001689817,0.0002045213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880677,0.009617049,1.286385e-7,0.001107032,0.0002137115,0.00009189721,0.00002583132,0.00001473003,0.0008618812],"genre_scores_gemma":[0.99635,0.0007721116,0.000417982,0.00003937788,0.001118007,0.000003687424,0.000001696008,0.0000234988,0.001273625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008844937,"threshold_uncertainty_score":0.7317259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348419672458079,"score_gpt":0.261865551028477,"score_spread":0.2483813543038962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}