{"id":"W2330446781","doi":"10.1021/np100657w","title":"Human Cytochrome P450 Liability Studies of <i>trans</i>-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer Cell Growth Inhibitor","year":2010,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Windsor","funders":"","keywords":"Amaryllidaceae Alkaloids; Alkaloid; Stereochemistry; CYP3A4; Chemistry; Enzyme; Cytochrome P450; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514889,0.0002279809,0.0002371292,0.0001351803,0.000120151,0.0001165701,0.0001353708,0.0001515502,0.001130807],"category_scores_gemma":[0.0001688391,0.00009887241,0.0001755319,0.0001453302,0.0001138183,0.0001159306,0.00009443118,0.0003079089,0.0002798238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857192,"about_ca_system_score_gemma":0.0001738668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594782,"about_ca_topic_score_gemma":0.002133459,"domain_scores_codex":[0.9999126,0.00002757046,0.000007695739,0.00001885511,0.00001985028,0.00001330459],"domain_scores_gemma":[0.9999148,0.00001975562,0.00001822554,0.0000114798,0.0000196923,0.00001610764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003618724,0.0001184581,0.0006165463,0.00007063446,0.00002401296,0.00009737436,0.00004026711,0.0001878916,0.9937734,0.00008051352,0.0001377644,0.004491204],"study_design_scores_gemma":[0.00004069299,0.003257321,0.00407495,0.000003345088,0.00004453415,0.0005491278,0.00002565782,0.0005985839,0.9883454,0.0000280224,0.003027489,0.000004906945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911643,0.003285399,0.002340768,0.00008021266,0.00002121754,0.00005380546,0.0005524448,0.00005797415,0.002443841],"genre_scores_gemma":[0.9945788,0.001860781,0.0009155601,0.00002887359,0.00001151455,0.00001746565,0.001035974,0.0000114007,0.00153968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001594782,"threshold_uncertainty_score":0.003782988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348419672458079,"score_gpt":0.261865551028477,"score_spread":0.2483813543038962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}