{"id":"W2330539453","doi":"10.1021/bi5006706","title":"Isotope Effects for Deuterium Transfer and Mutagenesis of Tyr187 Provide Insight into Controlled Radical Chemistry in Adenosylcobalamin-Dependent Ornithine 4,5-Aminomutase","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Adenosylcobalamin; Homolysis; Kinetic isotope effect; Active site; Stereochemistry; Aldimine; Enzyme kinetics; Lysine; Ornithine; Substrate (aquarium); Radical; Deuterium; Biochemistry; Enzyme; Cofactor; Arginine; Catalysis; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003250457,0.000319985,0.0005417657,0.00003709902,0.00005020047,0.00002177157,0.0002568963,0.0003822834,0.00001432156],"category_scores_gemma":[0.0004901464,0.0002982978,0.0001660365,0.00008216249,0.0002088779,0.000006649524,0.0000928814,0.0001082156,9.54199e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001617647,"about_ca_system_score_gemma":0.0001188822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002447464,"about_ca_topic_score_gemma":0.00000883178,"domain_scores_codex":[0.9983847,0.00006265851,0.0004572675,0.0005970114,0.000168715,0.0003297064],"domain_scores_gemma":[0.9991606,0.0000778215,0.00009509694,0.0004221052,0.00007444433,0.0001699108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001047596,0.0001677473,0.001784623,0.0009662093,0.00007158707,0.000004620512,0.00006975856,0.000006200871,0.9923001,0.00001989122,0.0001059219,0.003455735],"study_design_scores_gemma":[0.0100571,0.0001379405,0.0009786678,0.00004101457,0.00008642914,0.00001528728,0.00004248163,0.0001302718,0.9834697,0.00007015187,0.004636088,0.0003348119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910462,0.004536599,0.003077814,0.0001013281,0.00007984993,0.0006328135,0.00004641793,0.0000145405,0.0004644736],"genre_scores_gemma":[0.9977776,0.0002501045,0.0007142223,0.0001580742,0.0002360743,0.0002481858,0.0002231182,0.00003603426,0.0003566077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009009506,"threshold_uncertainty_score":0.9999469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002945944391744757,"score_gpt":0.2079616323208429,"score_spread":0.2050156879290982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}