{"id":"W2330539453","doi":"10.1021/bi5006706","title":"Isotope Effects for Deuterium Transfer and Mutagenesis of Tyr187 Provide Insight into Controlled Radical Chemistry in Adenosylcobalamin-Dependent Ornithine 4,5-Aminomutase","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Adenosylcobalamin; Homolysis; Kinetic isotope effect; Active site; Stereochemistry; Aldimine; Enzyme kinetics; Lysine; Ornithine; Substrate (aquarium); Radical; Deuterium; Biochemistry; Enzyme; Cofactor; Arginine; Catalysis; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001263584,0.0002183586,0.0001488558,0.0000667698,0.00008044783,0.0001768751,0.0002327942,0.0002283131,0.0008363011],"category_scores_gemma":[0.0001574178,0.0001292734,0.0001542279,0.00007216895,0.0002049694,0.000164133,0.000133052,0.0003596632,0.0001180061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003113642,"about_ca_system_score_gemma":0.0001342504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008008262,"about_ca_topic_score_gemma":0.001016953,"domain_scores_codex":[0.9999526,0.000005999084,0.000003648048,0.00001175475,0.00001444655,0.00001157863],"domain_scores_gemma":[0.9999385,0.00002204434,0.00001843898,0.000006760834,0.000005663383,0.00000844588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007941197,0.00001343277,0.0002665571,0.00002165409,0.000003913102,0.0000425675,0.00001755799,0.0002453284,0.997993,0.0002201086,0.000009577171,0.001086907],"study_design_scores_gemma":[0.000008873289,0.0000843834,0.001125074,0.000001793674,0.000005658071,0.00005528517,0.00001221443,0.001808947,0.9964572,0.00005430217,0.0003817483,0.000004426436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964097,0.000196176,0.002854813,0.00003203135,0.00000754838,0.00001051776,0.00005373791,0.00002893606,0.0004064942],"genre_scores_gemma":[0.9971426,0.0001645594,0.002138399,0.00001086482,0.000001464665,0.000007946361,0.00005014358,0.0000172645,0.0004668047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008363011,"threshold_uncertainty_score":0.002797723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002945944391744757,"score_gpt":0.2079616323208429,"score_spread":0.2050156879290982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}