{"id":"W2330566617","doi":"10.1371/journal.pone.0125225","title":"Vasoactive Intestinal Polypeptide Promotes Intestinal Barrier Homeostasis and Protection Against Colitis in Mice","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Child and Family Research Institute; University of Toronto; BC Children's Hospital; University of British Columbia","funders":"CH.I.L.D. Foundation; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation; Michael Smith Health Research BC; Child and Family Research Institute","keywords":"Vasoactive intestinal peptide; Colitis; Homeostasis; Paneth cell; Barrier function; Inflammatory bowel disease; Internal medicine; Endocrinology; Mucin 2; Biology; Intestinal mucosa; Goblet cell; Cell biology; Epithelium; Immunology; Neuropeptide; Small intestine; Medicine; Gene expression; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004411999,0.0007602645,0.0007407371,0.0009209873,0.0002912931,0.0005825032,0.0004991366,0.0007627466,0.002699671],"category_scores_gemma":[0.0002252071,0.0005062782,0.0005623678,0.0004192025,0.0006975812,0.0005175163,0.0006144236,0.002340693,0.0007813333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000349966,"about_ca_system_score_gemma":0.0003655508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003732887,"about_ca_topic_score_gemma":0.0006498016,"domain_scores_codex":[0.9994946,0.00008743456,0.00005111669,0.0001465156,0.0001102341,0.0001101999],"domain_scores_gemma":[0.9994247,0.00003439561,0.0001865405,0.00004548897,0.00002983535,0.0002790367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001317092,0.00020726,0.0003123885,0.0001569903,0.00001713743,0.0001494748,0.00003167167,0.0001114089,0.9949216,0.0002060037,0.0001910487,0.002377885],"study_design_scores_gemma":[0.001126499,0.00645325,0.02907953,0.000176569,0.0001876552,0.001623573,0.0002364895,0.003654145,0.9443165,0.0004923941,0.01260569,0.00004776698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814643,0.004390397,0.00685328,0.0008005903,0.0002619695,0.000167412,0.001916872,0.0008581551,0.003287017],"genre_scores_gemma":[0.9803688,0.003126611,0.006916753,0.0003215578,0.00006959961,0.0003641997,0.001468183,0.0001490955,0.007215162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002699671,"threshold_uncertainty_score":0.009031296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09800015610377417,"score_gpt":0.2517863978309232,"score_spread":0.1537862417271491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}