{"id":"W2330566617","doi":"10.1371/journal.pone.0125225","title":"Vasoactive Intestinal Polypeptide Promotes Intestinal Barrier Homeostasis and Protection Against Colitis in Mice","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Child and Family Research Institute; University of Toronto; BC Children's Hospital; University of British Columbia","funders":"CH.I.L.D. Foundation; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation; Michael Smith Health Research BC; Child and Family Research Institute","keywords":"Vasoactive intestinal peptide; Colitis; Homeostasis; Paneth cell; Barrier function; Inflammatory bowel disease; Internal medicine; Endocrinology; Mucin 2; Biology; Intestinal mucosa; Goblet cell; Cell biology; Epithelium; Immunology; Neuropeptide; Small intestine; Medicine; Gene expression; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166099,0.0001650426,0.0002294505,0.0001190443,0.0000755388,0.00005066914,0.0001351848,0.00004299643,0.00001230034],"category_scores_gemma":[0.001804672,0.000157442,0.00002282126,0.0002952822,0.0001952888,0.0002487935,0.0001414497,0.000332997,0.0000567913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006511519,"about_ca_system_score_gemma":0.00006611204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001603316,"about_ca_topic_score_gemma":0.00005440878,"domain_scores_codex":[0.9986137,0.0001793202,0.0002057587,0.0004705061,0.0002157331,0.0003149519],"domain_scores_gemma":[0.9993623,0.0001570689,0.00009455258,0.0001202886,0.00008913593,0.0001765828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002481536,0.0004701833,0.001022058,0.00004179874,0.000007115289,0.0000623173,0.0002381015,0.000002155665,0.9954973,0.0001402465,0.00001257235,0.002257952],"study_design_scores_gemma":[0.0005882321,0.001297329,0.0114575,0.0002985525,0.00002163101,0.00005814746,0.000154075,0.0009143443,0.9837782,0.001153525,0.00005110017,0.0002273262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997533,0.00002761113,0.000007357604,0.0001975181,0.00002639233,0.0004900543,0.00001395354,0.0000788888,0.00162524],"genre_scores_gemma":[0.9984662,0.00002715643,0.0007677148,0.0004084519,0.00009014691,0.00007076967,0.000001346126,0.0000245964,0.000143624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01171911,"threshold_uncertainty_score":0.6420298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09800015610377417,"score_gpt":0.2517863978309232,"score_spread":0.1537862417271491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}