{"id":"W2330734534","doi":"10.1021/ac503358m","title":"Intracellular Detection of ATP Using an Aptamer Beacon Covalently Linked to Graphene Oxide Resisting Nonspecific Probe Displacement","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"China Postdoctoral Science Foundation; Ministry of Education of the People's Republic of China; Natural Sciences and Engineering Research Council of Canada; Natural Science Foundation of Hainan Province; National Natural Science Foundation of China","keywords":"Aptamer; Covalent bond; Chemistry; Graphene; Fluorophore; Molecular beacon; Intracellular; Fluorescence; Biophysics; Nanotechnology; Biochemistry; DNA; Oligonucleotide; Materials science; Molecular biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003302127,0.0002116517,0.0002704921,0.00004692667,0.0001004629,0.00002241846,0.0001658333,0.0002147538,0.000004859068],"category_scores_gemma":[0.0002044858,0.0002009793,0.0001585341,0.0002283499,0.0001370689,0.000005863203,0.00009153179,0.0001358569,0.000001200946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003703183,"about_ca_system_score_gemma":0.00002418745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002613665,"about_ca_topic_score_gemma":0.000010224,"domain_scores_codex":[0.9985242,0.00004691569,0.0004002458,0.0005349739,0.0002136961,0.0002799944],"domain_scores_gemma":[0.9989465,0.00001748062,0.0001554784,0.0005246875,0.0001767402,0.0001790478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000999246,0.0001150215,0.0003965883,0.00005097673,0.00006264578,0.000001590479,0.000007346527,0.0001116825,0.9977012,0.00001471061,0.00001425743,0.001424081],"study_design_scores_gemma":[0.0001819572,0.0001529692,0.0002786848,0.000048316,0.0001273773,0.000007613727,0.00005217837,0.004905641,0.9919317,0.00005175859,0.002009402,0.0002524278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8890678,0.00004225955,0.1104721,0.00005034332,0.00001554731,0.00009927581,0.000007176933,0.00003314472,0.0002123884],"genre_scores_gemma":[0.9879642,0.0000156729,0.01142837,0.0000837518,0.0001985893,0.000004938948,0.00007888674,0.00002517792,0.0002004507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09904368,"threshold_uncertainty_score":0.8195699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715792696915264,"score_gpt":0.2789357863851386,"score_spread":0.2617778594159859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}