{"id":"W2330734534","doi":"10.1021/ac503358m","title":"Intracellular Detection of ATP Using an Aptamer Beacon Covalently Linked to Graphene Oxide Resisting Nonspecific Probe Displacement","year":2014,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"China Postdoctoral Science Foundation; Ministry of Education of the People's Republic of China; Natural Sciences and Engineering Research Council of Canada; Natural Science Foundation of Hainan Province; National Natural Science Foundation of China","keywords":"Aptamer; Covalent bond; Chemistry; Graphene; Fluorophore; Molecular beacon; Intracellular; Fluorescence; Biophysics; Nanotechnology; Biochemistry; DNA; Oligonucleotide; Materials science; Molecular biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010647,0.0004428914,0.0002366154,0.0002226608,0.0001260808,0.0001995664,0.000433164,0.0006046661,0.0003343449],"category_scores_gemma":[0.0003496635,0.0001943676,0.0001725025,0.0001997539,0.0003186745,0.0002688997,0.00028542,0.0003411696,0.000170828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379057,"about_ca_system_score_gemma":0.0001511007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004841271,"about_ca_topic_score_gemma":0.001192369,"domain_scores_codex":[0.9996992,0.00004252255,0.00001657975,0.0001026287,0.0001052755,0.00003390578],"domain_scores_gemma":[0.9998336,0.00004428972,0.00005844927,0.00001742385,0.00002865929,0.00001771772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005015787,0.000002410387,0.00003157602,0.00001458793,0.000001106377,0.00001419176,0.000006338639,0.00002995096,0.9990152,0.00003313506,0.00000703896,0.0008395299],"study_design_scores_gemma":[0.000001702877,0.00007992167,0.0004200049,0.000001793381,0.000005447236,0.00008067783,0.000005390057,0.000703618,0.9980327,0.00002252829,0.0006423508,0.000003730832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8897109,0.002792096,0.1049823,0.0002333083,0.0001076815,0.00007727022,0.0001288739,0.0003289606,0.001638551],"genre_scores_gemma":[0.9277233,0.001351058,0.06766722,0.0001934373,0.00002838471,0.00008242831,0.0001915008,0.0000238497,0.002738727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006046661,"threshold_uncertainty_score":0.001726151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715792696915264,"score_gpt":0.2789357863851386,"score_spread":0.2617778594159859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}