{"id":"W2330766351","doi":"10.1016/j.freeradbiomed.2012.10.313","title":"Cysteine 146 of CuZnSOD is Oxidized to Sulfonic Acid During Aging of Yeast: A Potential Mechanism Underlying Sporadic ALS Onset","year":2012,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"","keywords":"Cysteine; Mechanism (biology); Chemistry; Yeast; Sulfonic acid; Biochemistry; Cell biology; Biology; Polymer chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005186109,0.0001396622,0.0003388871,0.0001268461,0.00006373507,0.000001165592,0.0002042871,0.0001731315,0.00009591509],"category_scores_gemma":[0.0006266339,0.0001120496,0.00004369383,0.0001564003,0.000415774,0.000006529044,0.0001773498,0.0001366606,0.000002967617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001136342,"about_ca_system_score_gemma":0.00005148324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003416083,"about_ca_topic_score_gemma":0.00000378165,"domain_scores_codex":[0.9987602,0.0001127071,0.0003358522,0.0002939823,0.0001408165,0.0003565055],"domain_scores_gemma":[0.9991598,0.00002300734,0.0001222474,0.0003849744,0.00008043003,0.000229504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002433893,0.00004387653,0.0008355635,0.00008040246,0.00006836553,0.000002293639,0.0001764774,0.000001276841,0.9963574,0.0007911035,0.000252543,0.001147346],"study_design_scores_gemma":[0.002469576,0.0007709391,0.004188966,0.00008298373,0.00004314897,0.0001136119,0.0001201257,0.000007882364,0.9872587,0.001469066,0.003336397,0.0001386526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819489,0.006479027,0.008561078,0.002448821,0.0002037659,0.0002348109,0.00004984126,0.00000878126,0.0000649639],"genre_scores_gemma":[0.9965539,0.0006721901,0.001829458,0.000279053,0.0003130795,0.00001077158,0.00008360661,0.00001388172,0.000244056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01460499,"threshold_uncertainty_score":0.4569251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02302247418994102,"score_gpt":0.3391418918654554,"score_spread":0.3161194176755144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}