{"id":"W2330853407","doi":"10.1242/dev.114835","title":"A dynamic <i>Shh</i> expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face","year":2015,"lang":"en","type":"article","venue":"Development","topic":"dental development and anomalies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"National Institute of Dental and Craniofacial Research","keywords":"Primordium; Biology; Ectoderm; Bone morphogenetic protein; Cell biology; Morphogenesis; Sonic hedgehog; Anatomy; Amniote; Mesenchyme; FGF8; Embryo; Embryogenesis; Vertebrate; Signal transduction; Genetics; Fibroblast growth factor; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006717131,0.0001722063,0.00008652357,0.0001960929,0.0002186678,0.0002854417,0.0001959213,0.0001833292,0.0004493289],"category_scores_gemma":[0.0001348084,0.0001753457,0.0001138433,0.00008508566,0.0003877616,0.0001653604,0.0003071876,0.0003013435,0.0002375367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522545,"about_ca_system_score_gemma":0.0003738068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009983339,"about_ca_topic_score_gemma":0.001266713,"domain_scores_codex":[0.9999111,0.000007201233,0.000004210789,0.00002649879,0.00003347072,0.00001755091],"domain_scores_gemma":[0.9999235,0.000008444898,0.00003338334,0.00000846015,0.00001164846,0.00001459593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001343495,0.000001920812,0.0007896558,0.000008934639,0.000001021721,0.00005004693,0.00002298801,0.00007688846,0.996842,0.000366417,0.00001504985,0.00181155],"study_design_scores_gemma":[0.000008427214,0.0001541263,0.06441555,0.000009406904,0.0000177547,0.0007808742,0.0002113703,0.002689434,0.9269925,0.000499748,0.004209007,0.00001178484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988438,0.0003943697,0.007868224,0.00005026827,0.000008933849,0.0000116209,0.00008387994,0.00009633764,0.003048391],"genre_scores_gemma":[0.9944304,0.0001783582,0.003818042,0.00001955027,0.000004913492,0.00001193024,0.00008215257,0.00001423002,0.001440504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009983339,"threshold_uncertainty_score":0.001985013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007022816770089481,"score_gpt":0.2198152292937251,"score_spread":0.2127924125236356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}