{"id":"W2330927692","doi":"10.1097/cad.0000000000000096","title":"LC-based targeted metabolomics analysis of nucleotides and identification of biomarkers associated with chemotherapeutic drugs in cultured cell models","year":2014,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Drug action; Drug; Nucleotide; Mechanism of action; Pharmacology; Computational biology; Metabolomics; Biology; Chemistry; Biochemistry; Cancer research; Bioinformatics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000586955,0.000869208,0.000753686,0.001362849,0.0003599399,0.0006152701,0.0002576777,0.0006431484,0.0006350106],"category_scores_gemma":[0.0007643288,0.0002307743,0.0006298465,0.001299319,0.0003665827,0.0004795552,0.0004377818,0.0007202543,0.0002997326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004074898,"about_ca_system_score_gemma":0.0005982698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001835053,"about_ca_topic_score_gemma":0.002823017,"domain_scores_codex":[0.9994175,0.00009143223,0.00005039255,0.0001664937,0.0002211741,0.00005297802],"domain_scores_gemma":[0.9996992,0.00008196296,0.00006734634,0.00003414291,0.00009920348,0.00001823541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234138,0.00005184194,0.001628753,0.0001297557,0.00003719545,0.00007059021,0.00004331395,0.0005215304,0.9892489,0.000127403,0.00007691503,0.007940388],"study_design_scores_gemma":[0.00001046184,0.0003547814,0.01500023,0.00001664035,0.0001294208,0.0001825647,0.00008130492,0.009142151,0.9725899,0.0002777115,0.002173671,0.00004127357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8023441,0.008231845,0.1794698,0.0002801791,0.000177743,0.000596016,0.004220949,0.0007808461,0.003898434],"genre_scores_gemma":[0.8153754,0.009099769,0.16431,0.0006709212,0.00008387514,0.001837765,0.004472411,0.0001850149,0.003964688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001835053,"threshold_uncertainty_score":0.003648758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006977960851828034,"score_gpt":0.2304244932160295,"score_spread":0.2234465323642015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}