{"id":"W2331078114","doi":"10.1097/ccm.0000000000001424","title":"Modulation by the Noble Gas Helium of Tissue Plasminogen Activator: Effects in a Rat Model of Thromboembolic Stroke*","year":2015,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Anesthesia and Neurotoxicity Research","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Medicine; Tissue plasminogen activator; Thrombolysis; Neuroprotection; Plasminogen activator; Ischemia; T-plasminogen activator; Brain ischemia; Activator (genetics); Pharmacology; In vivo; Internal medicine; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002614313,0.0001233923,0.0003482989,0.0000903843,0.0000416334,0.000006006152,0.0002825519,0.00007790311,0.00001521773],"category_scores_gemma":[0.003496144,0.00008076474,0.00003043187,0.0002646792,0.0007245594,0.0001021414,0.00006588055,0.0002334359,0.000006025783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004224096,"about_ca_system_score_gemma":0.00009100626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007820388,"about_ca_topic_score_gemma":0.000006163429,"domain_scores_codex":[0.9981588,0.0002801941,0.0002603284,0.0002594855,0.0007594687,0.0002817499],"domain_scores_gemma":[0.9982178,0.001151484,0.00003802003,0.0002879825,0.0001416379,0.0001630502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008149557,0.00007705617,0.0007586591,0.0002301347,9.152627e-7,0.00001416218,0.001466215,0.0002106762,0.9935191,0.002526881,0.0004969897,0.0006177234],"study_design_scores_gemma":[0.0007702966,0.0007814745,0.0001895904,0.00008321234,0.00001349942,0.00001252086,0.0006209238,0.01839076,0.9780621,0.0009257587,0.00008152179,0.00006834217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951557,0.0002074996,0.0009332048,0.002042851,0.000076951,0.0004961275,0.00001234584,0.00001521451,0.001060131],"genre_scores_gemma":[0.9994451,0.00001155348,0.00002890454,0.0003540419,0.00004842949,0.000032391,0.000002639966,0.00001537748,0.00006150632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01818009,"threshold_uncertainty_score":0.4185464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06808308345307985,"score_gpt":0.3537828276424748,"score_spread":0.2856997441893949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}