{"id":"W2331113362","doi":"10.1021/bc400565y","title":"General Chemoselective and Redox-Responsive Ligation and Release Strategy","year":2014,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; National Science Foundation","keywords":"Chemistry; Redox; Combinatorial chemistry; Nanotechnology; Small molecule; Click chemistry; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001093188,0.0002662383,0.0002230525,0.00001204429,0.00020029,0.00008766157,0.0001355751,0.0002600381,0.0002947836],"category_scores_gemma":[0.0001788558,0.000285422,0.00004694241,0.00009990294,0.0002452833,0.00008381428,0.00009199284,0.0002606804,0.00001042249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004825665,"about_ca_system_score_gemma":0.00005274231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002420177,"about_ca_topic_score_gemma":0.000001142967,"domain_scores_codex":[0.9987187,0.00001136762,0.0002660583,0.0005903696,0.0001313266,0.0002821294],"domain_scores_gemma":[0.9990135,0.0001174631,0.0001436045,0.0003781257,0.00009572967,0.0002515323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005239388,0.00004091346,0.0002386558,0.0002182656,0.00002609684,0.000002545777,0.00006754931,0.00000291458,0.9943165,0.0003088371,0.0004048194,0.004320495],"study_design_scores_gemma":[0.0006708616,0.00001129213,0.0002845185,0.00004509699,0.00003698321,0.00006713357,0.0001766183,0.000750793,0.9852087,0.001759895,0.01065926,0.0003288556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739329,0.000240029,0.00003818196,0.0003747118,0.000008783345,0.00007178123,0.00004833625,0.0001187716,0.02516657],"genre_scores_gemma":[0.9928434,0.0001301304,0.0002109429,0.0001003602,0.0003861663,0.00008081431,0.0001496243,0.00002954206,0.006069008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01909756,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008038976957725284,"score_gpt":0.2331693949590861,"score_spread":0.2251304180013608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}