{"id":"W2331135699","doi":"10.1097/nen.0000000000000219","title":"Evidence for Epigenetic Regulation of Gene Expression and Function in Chronic Experimental Diabetic Neuropathy","year":2015,"lang":"en","type":"article","venue":"Journal of Neuropathology & Experimental Neurology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Downregulation and upregulation; Biology; Diabetic neuropathy; microRNA; Sensory neuron; Dorsal root ganglion; Endocrinology; Messenger RNA; Gene expression; Diabetes mellitus; Internal medicine; Neuron; Sensory system; Neuroscience; Gene; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290221,0.0002383387,0.0001516599,0.0002747387,0.0001215029,0.0002159817,0.0001622055,0.0002112332,0.00105735],"category_scores_gemma":[0.0001759637,0.0001058101,0.0002004262,0.0001431618,0.0003162991,0.0001592432,0.0002268908,0.0003943218,0.00009139477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002660344,"about_ca_system_score_gemma":0.0001490853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003327848,"about_ca_topic_score_gemma":0.0005421116,"domain_scores_codex":[0.9998676,0.00001716012,0.00001351815,0.0000448352,0.00003885007,0.00001807813],"domain_scores_gemma":[0.9998015,0.00003538104,0.0000811718,0.00003154559,0.00002472813,0.00002582222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001794127,0.00003597361,0.001400636,0.00006882083,0.00001764688,0.0001043997,0.00002298055,0.00003457925,0.9952244,0.0001535077,0.00003150943,0.00272611],"study_design_scores_gemma":[0.00005293961,0.001161478,0.1456621,0.00004319948,0.0001246709,0.001431477,0.0001111824,0.0008872698,0.846126,0.0003579694,0.004028766,0.00001290186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907758,0.003303907,0.004330027,0.0001238826,0.00003463465,0.00001775248,0.0003671977,0.00005881167,0.0009881296],"genre_scores_gemma":[0.9945182,0.002053563,0.001729478,0.00008375416,0.00001425176,0.00004253941,0.0003352068,0.00001308213,0.001209982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105735,"threshold_uncertainty_score":0.003537238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390120546948832,"score_gpt":0.2929207581766975,"score_spread":0.2590195527072092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}