{"id":"W2331169930","doi":"10.2174/2211556011302020003","title":"From Preclinical to Clinical Trials: An Update on Potential Therapies for Huntington’s Disease","year":2013,"lang":"en","type":"article","venue":"Current Psychopharmacologye","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Huntington's disease; Disease; Clinical trial; Neurodegeneration; Medicine; Neuroscience; Huntingtin Protein; Striatum; Bioinformatics; Huntingtin; Psychiatry; Psychology; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001500869,0.0003965529,0.0006890022,0.0001320624,0.0002391316,0.000189034,0.0008737717,0.0001064672,0.002650163],"category_scores_gemma":[0.005987972,0.0003318993,0.0005334805,0.0001737127,0.0002474933,0.0002253321,0.0001253256,0.0004026318,0.001334183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002148983,"about_ca_system_score_gemma":0.0001210975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002919333,"about_ca_topic_score_gemma":7.107369e-7,"domain_scores_codex":[0.9918269,0.004247438,0.001311563,0.001656718,0.0003614312,0.0005959613],"domain_scores_gemma":[0.9941407,0.003461736,0.0003928055,0.0006628628,0.0001515928,0.001190324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006250929,0.006156552,0.003982076,0.00003170123,0.00008938187,0.000005790987,0.000173052,0.0003497791,0.3687469,0.0002172845,0.2938838,0.3201127],"study_design_scores_gemma":[0.030089,0.004508174,0.2125738,0.000144484,0.00135914,0.000001198651,0.0001301908,0.01258712,0.3745386,0.02498691,0.3362371,0.002844179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695101,0.0002337161,0.001745387,0.006256541,0.01794792,0.003379008,0.0007245885,0.0001745302,0.00002821121],"genre_scores_gemma":[0.9776803,0.0003004297,0.0004985716,0.01450056,0.005122795,0.001669051,0.00005007324,0.00006462973,0.0001136489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3172686,"threshold_uncertainty_score":0.9999133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2694692517632758,"score_gpt":0.5281278152306261,"score_spread":0.2586585634673503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}