{"id":"W2331177117","doi":"10.1016/j.cjca.2011.08.095","title":"701 Cardiac-specific disruption of BRCA2 results in higher doxorubicin sensitivity and heart failure with advanced age","year":2011,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Medicine; Heart failure; Doxorubicin; Internal medicine; Cardiology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777367,0.0002534626,0.0003929491,0.0005581407,0.0002577728,0.000300596,0.000202205,0.00039439,0.003605858],"category_scores_gemma":[0.0002888457,0.0002582816,0.0003580801,0.0002629396,0.000318625,0.00022592,0.0003089754,0.0007584178,0.0003552418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798807,"about_ca_system_score_gemma":0.0002463874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002160598,"about_ca_topic_score_gemma":0.002732979,"domain_scores_codex":[0.9997935,0.00002431257,0.00001456783,0.00005249231,0.00005371997,0.00006148033],"domain_scores_gemma":[0.9996623,0.00004314584,0.0001248164,0.00002476504,0.00002464644,0.0001203676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001333205,0.0002227463,0.011393,0.00002229823,0.00003216333,0.0008734179,0.00007125492,0.0000929148,0.982781,0.0001373399,0.0002298661,0.00281074],"study_design_scores_gemma":[0.0001437968,0.002580023,0.6366539,0.00001936403,0.0001589734,0.008919504,0.0003244784,0.001378235,0.345043,0.0002757016,0.00445889,0.00004403156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981681,0.0002446245,0.0005547557,0.00008281497,0.00002117001,0.00001081974,0.0002680796,0.00002960918,0.0006198933],"genre_scores_gemma":[0.9973862,0.0001560178,0.0003393522,0.00005532468,0.000008799361,0.0000122896,0.0002317811,0.00001564384,0.001794665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003605858,"threshold_uncertainty_score":0.01206285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02734903098914172,"score_gpt":0.2324440303123353,"score_spread":0.2050949993231936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}