{"id":"W2331181498","doi":"10.1021/bi301046b","title":"By Increasing the Affinity of Heparin for Fibrin, Zn<sup>2+</sup> Promotes the Formation of a Ternary Heparin–Thrombin–Fibrin Complex That Protects Thrombin from Inhibition by Antithrombin","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Thrombin; Fibrin; Antithrombin; Chemistry; Ternary complex; Heparin; Discovery and development of direct thrombin inhibitors; Biochemistry; Biophysics; Immunology; Platelet; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001297075,0.0004885638,0.000417041,0.0001564925,0.0001311077,0.0005239367,0.0005236896,0.0003537438,0.00137493],"category_scores_gemma":[0.0002841357,0.0002591034,0.0002073735,0.0001375743,0.0003463046,0.0002822956,0.0003712123,0.0003272384,0.0004654264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005010098,"about_ca_system_score_gemma":0.0001970647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569205,"about_ca_topic_score_gemma":0.002271723,"domain_scores_codex":[0.9998092,0.0000286652,0.00002067737,0.00004753014,0.00005996323,0.00003409681],"domain_scores_gemma":[0.9998645,0.00002662146,0.00004393564,0.00001212739,0.000025929,0.00002682043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002425364,0.00002656218,0.0004700283,0.0001311299,0.00001300946,0.00006564943,0.00001402214,0.0001252459,0.9961985,0.0001476462,0.0001663303,0.002399296],"study_design_scores_gemma":[0.00005956964,0.0001797477,0.003536082,0.000008141642,0.00002178052,0.0002922601,0.00002965661,0.002598634,0.9882767,0.0001234161,0.004864201,0.000009811071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9693526,0.003510474,0.02194262,0.0004007799,0.000126056,0.000107164,0.0004018814,0.0005718187,0.003586591],"genre_scores_gemma":[0.9819068,0.0009292844,0.01308714,0.0001856504,0.00003501487,0.00006564593,0.0003593444,0.00007859876,0.00335249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001569205,"threshold_uncertainty_score":0.004599571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04028950542584198,"score_gpt":0.2712617442265609,"score_spread":0.2309722388007189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}