{"id":"W2331216768","doi":"10.1021/ja4021974","title":"Enantioselective Ketone Hydroacylation Using Noyori’s Transfer Hydrogenation Catalyst","year":2013,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hydroacylation; Enantioselective synthesis; Chemistry; Chemoselectivity; Ketone; Aldehyde; Transfer hydrogenation; Noyori asymmetric hydrogenation; Organic chemistry; Alcohol; Catalysis; Reactivity (psychology); Combinatorial chemistry; Ruthenium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338775,0.0004209021,0.0003275993,0.0001948048,0.0001978851,0.0001752411,0.0004291569,0.0003577721,0.0007735275],"category_scores_gemma":[0.0001973396,0.0001974415,0.00022572,0.0001787276,0.0002478572,0.0004273826,0.0005550631,0.0006580022,0.0005178247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499429,"about_ca_system_score_gemma":0.0003101421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009711689,"about_ca_topic_score_gemma":0.001241308,"domain_scores_codex":[0.9998071,0.00002236981,0.00001430053,0.0000421421,0.00005154615,0.0000626909],"domain_scores_gemma":[0.9999495,0.000008209508,0.000009632237,0.000009892306,0.0000115327,0.00001125405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001434752,0.00008873839,0.0002966444,0.0001382123,0.00002350013,0.0004559405,0.0001265292,0.0003820382,0.9797841,0.001512945,0.0006494246,0.01639852],"study_design_scores_gemma":[0.00003113619,0.00010216,0.0004580127,0.000004632031,0.00001446393,0.0002235874,0.00002024122,0.0013264,0.9934313,0.0001151327,0.004257133,0.00001588121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947327,0.002078886,0.03029338,0.0004609315,0.0002487958,0.0001306198,0.000179551,0.0002937558,0.01898702],"genre_scores_gemma":[0.9879823,0.001090864,0.005964071,0.00006064479,0.0000192859,0.00003971887,0.0001492635,0.00003301766,0.004660822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009711689,"threshold_uncertainty_score":0.002587676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01023028788449644,"score_gpt":0.2374123684884313,"score_spread":0.2271820806039348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}