{"id":"W2331427771","doi":"10.1158/1535-7163.targ-09-c218","title":"Abstract C218: Antitumor activities of a novel oral formulation of SN38","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Tolerability; Irinotecan; Pharmacology; Pharmacokinetics; In vivo; Active metabolite; Chemistry; Prodrug; Bioavailability; SN-38; Oral administration; Bioequivalence; Medicine; In vitro; Metabolite; Colorectal cancer; Cancer; Biochemistry; Adverse effect; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008118783,0.0003511457,0.0001622146,0.0001986765,0.00009578174,0.0001302439,0.0001834435,0.0001923168,0.002029261],"category_scores_gemma":[0.00008330493,0.000066539,0.0001121638,0.0001277007,0.00008644151,0.0001467412,0.0001038331,0.0003378818,0.0003751157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002460367,"about_ca_system_score_gemma":0.0001932091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006287789,"about_ca_topic_score_gemma":0.0007519596,"domain_scores_codex":[0.9999547,0.000006829689,0.000003252412,0.000009942845,0.00001664177,0.000008663921],"domain_scores_gemma":[0.9999642,0.000004479054,0.000009826503,0.000003098818,0.000007509535,0.00001091529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004689975,0.0003220073,0.0001147451,0.0001128743,0.000009028644,0.00009463928,0.00001478335,0.0003004287,0.9846976,0.00009213574,0.0002660004,0.01350688],"study_design_scores_gemma":[0.0002063423,0.005548182,0.001662491,0.00001484214,0.00003696212,0.0004901557,0.00001290958,0.00148943,0.9809119,0.00003733328,0.009580856,0.000008608268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990961,0.003169081,0.001974129,0.0001125939,0.00004436795,0.0001276887,0.0004067149,0.00006182177,0.003142506],"genre_scores_gemma":[0.9900933,0.001808665,0.003320421,0.00004244176,0.00002749956,0.00007127484,0.000567983,0.00001698027,0.004051439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002029261,"threshold_uncertainty_score":0.006788611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05436867551825783,"score_gpt":0.3722591213640159,"score_spread":0.3178904458457581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}