{"id":"W2331431498","doi":"10.1021/ja410344b","title":"Anti-frameshifting Ligand Reduces the Conformational Plasticity of the SARS Virus Pseudoknot","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Technology Futures","keywords":"Chemistry; Pseudoknot; Translational frameshift; Ligand (biochemistry); Virology; Mutation; Base sequence; Biochemistry; Gene; Frameshift mutation; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001259523,0.0002191767,0.0002062177,0.00007582721,0.0001055156,0.0001721805,0.0001555589,0.0002190115,0.001121487],"category_scores_gemma":[0.0001771139,0.00008450637,0.000111047,0.00003124312,0.0001733918,0.0001402721,0.0001183905,0.0002970049,0.0001602714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489688,"about_ca_system_score_gemma":0.0001406903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001882318,"about_ca_topic_score_gemma":0.0003886438,"domain_scores_codex":[0.9999161,0.00001882815,0.000005293551,0.00001566713,0.00002064449,0.00002360113],"domain_scores_gemma":[0.9999121,0.00002952472,0.00002434592,0.000005768441,0.00001015359,0.00001815696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001089604,0.00003418409,0.00008133139,0.00001915624,0.000002303843,0.00001034881,0.000008054787,0.0001310941,0.9987519,0.00005899545,0.0000163936,0.0007774486],"study_design_scores_gemma":[0.00001733519,0.0005394585,0.001386516,0.000003448023,0.000003662426,0.00004786259,0.00001680484,0.002100141,0.9953671,0.00003700419,0.0004759275,0.000004766665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986739,0.0002720742,0.0006211867,0.00003220285,0.00001180571,0.000007231147,0.00002018903,0.00001774769,0.0003436725],"genre_scores_gemma":[0.9983626,0.0001319998,0.0008558313,0.0000375344,0.000004821588,0.000009480249,0.0000505723,0.000006229692,0.0005409107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121487,"threshold_uncertainty_score":0.003751755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008240419804008336,"score_gpt":0.2363291027169899,"score_spread":0.2280886829129816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}