{"id":"W2331513443","doi":"10.1515/hc.2002.8.2.115","title":"Design and Synthesis of Novel DNA Interstrand Cross-Linking Agents: C2-Linked Pyrrolo[2,1-c][1,4]benzodiazepine Polyamide Conjugates","year":2002,"lang":"en","type":"article","venue":"Heterocyclic Communications","topic":"Synthesis and pharmacology of benzodiazepine derivatives","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Conjugate; Benzodiazepine; Combinatorial chemistry; Polyamide; Stereochemistry; DNA; Organic chemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002370413,0.0005733338,0.0002563672,0.0002332904,0.0002066416,0.0003233474,0.0002873358,0.0003762392,0.001212754],"category_scores_gemma":[0.0002573747,0.0002288983,0.0001440498,0.0001631719,0.0001990899,0.000383041,0.000182971,0.0005526372,0.0004397321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003828866,"about_ca_system_score_gemma":0.0003440997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002188138,"about_ca_topic_score_gemma":0.0005292366,"domain_scores_codex":[0.9998857,0.0000235406,0.00001331695,0.0000296279,0.00002626246,0.0000215321],"domain_scores_gemma":[0.9998364,0.00002382487,0.00005637783,0.00001217499,0.00003032861,0.00004084018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129078,0.00008918709,0.00007183395,0.0001122968,0.000007799557,0.00009132292,0.00004542256,0.0006595873,0.9911981,0.0006182566,0.00008891211,0.006904275],"study_design_scores_gemma":[0.00007367432,0.0006323531,0.0001737048,0.000005781068,0.00001392237,0.0001437235,0.000005810895,0.000584705,0.9933794,0.00004380134,0.004937412,0.000005734138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9266079,0.005163506,0.05916309,0.0003270037,0.0001609912,0.001026449,0.0003705752,0.0002681645,0.006912335],"genre_scores_gemma":[0.9392289,0.003920582,0.04815572,0.0001656722,0.00004865304,0.0007499558,0.0004781752,0.00005487152,0.007197472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212754,"threshold_uncertainty_score":0.00405705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1044061136674993,"score_gpt":0.3292462849153485,"score_spread":0.2248401712478491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}