{"id":"W2331519665","doi":"10.1158/0008-5472.can-15-2347","title":"A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence","year":2016,"lang":"en","type":"article","venue":"Cancer Research","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Senescence; Cyclin-dependent kinase; Biology; Epigenetics; Cancer research; Cell biology; DNA methylation; Kinase; Retinoblastoma protein; Cancer; Cell cycle; Gene expression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004841315,0.0002267146,0.0001976322,0.0000770093,0.000200077,0.00005838925,0.0006746176,0.0002826464,0.0005017298],"category_scores_gemma":[0.0001266266,0.0001650199,0.00007944423,0.0002045769,0.0001730914,0.000008282515,0.0003503155,0.0002704417,0.0001179234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968093,"about_ca_system_score_gemma":0.0009981182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213257,"about_ca_topic_score_gemma":0.0003486999,"domain_scores_codex":[0.9972355,0.0002649522,0.0002326696,0.0008585134,0.0006636159,0.0007447773],"domain_scores_gemma":[0.9985619,0.00005129915,0.00007504698,0.0006808181,0.0004070851,0.0002238796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001126892,0.00003436369,0.0002015299,0.00005191088,0.00005001647,0.00001813203,0.00006394906,0.000005045024,0.9850664,0.00004393687,0.0006023165,0.01374972],"study_design_scores_gemma":[0.000661971,0.0001979016,0.0001060843,0.0001773005,0.00001003313,0.000002295297,0.00005999555,0.000005792139,0.9915978,0.0009731831,0.005937929,0.0002696664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914016,0.003818694,0.002627,0.0005667338,0.0004108148,0.0006244955,0.00009060223,0.00002597295,0.0004340487],"genre_scores_gemma":[0.9877111,0.005985904,0.0001361803,0.0001112289,0.0008536512,0.001001617,0.000009523872,0.00006068376,0.004130096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01348006,"threshold_uncertainty_score":0.6729314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04748211863294191,"score_gpt":0.3543597841666069,"score_spread":0.306877665533665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}