{"id":"W2331638006","doi":"10.1021/jm3006788","title":"Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Hepatitis C virus; Virology; Replicon; ADME; Genotype; Polymerase; Allosteric regulation; Drug discovery; Chemistry; Virus; Pharmacology; Hepacivirus; Drug; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001292567,0.0002744471,0.0003848521,0.000223342,0.0001345617,0.0002194837,0.0001453658,0.000152644,0.001001867],"category_scores_gemma":[0.0001983226,0.0001257598,0.0001742301,0.0001363866,0.0001872383,0.0001333432,0.0002322958,0.0003714332,0.0002072441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978079,"about_ca_system_score_gemma":0.0003768063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005435435,"about_ca_topic_score_gemma":0.001906489,"domain_scores_codex":[0.9999549,0.00001077986,0.000002807292,0.00000899062,0.00001174321,0.00001059646],"domain_scores_gemma":[0.9999609,0.00000655481,0.000009869568,0.000002585287,0.000004794801,0.00001527211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001530287,0.0003278656,0.00207133,0.0001873594,0.00003357366,0.000376144,0.0001021705,0.001406702,0.9132738,0.0004663565,0.000542529,0.07968193],"study_design_scores_gemma":[0.001324631,0.0180776,0.01148375,0.00004274686,0.0001911252,0.00289667,0.00007273872,0.005844247,0.9457759,0.0003693804,0.01386287,0.00005848986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853519,0.005213199,0.005558158,0.0003129294,0.00003225467,0.0001723743,0.0004002227,0.0001139054,0.002844899],"genre_scores_gemma":[0.9918411,0.001736867,0.004864939,0.00008062818,0.00001097414,0.00003563351,0.0003525595,0.000009868727,0.001067279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001867,"threshold_uncertainty_score":0.003351569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008810261783390984,"score_gpt":0.2503778863884722,"score_spread":0.2415676246050812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}