{"id":"W2331638006","doi":"10.1021/jm3006788","title":"Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Hepatitis C virus; Virology; Replicon; ADME; Genotype; Polymerase; Allosteric regulation; Drug discovery; Chemistry; Virus; Pharmacology; Hepacivirus; Drug; Biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005575196,0.0002708601,0.000684935,0.0001095765,0.00007919409,0.0000202228,0.0002583731,0.0001895897,0.0001170067],"category_scores_gemma":[0.0005299508,0.0001560018,0.0001245038,0.0006046006,0.0005121505,0.0004523899,0.0000865149,0.001257063,0.000002401964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004113845,"about_ca_system_score_gemma":0.001273457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007074802,"about_ca_topic_score_gemma":0.0004678482,"domain_scores_codex":[0.9969516,0.0001181649,0.0006590449,0.0001975928,0.001538647,0.0005348973],"domain_scores_gemma":[0.9980638,0.0001707493,0.0006674283,0.0003733551,0.0004350409,0.0002896157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003461587,0.00116274,0.8888702,0.0002942162,0.0001758786,0.0001323905,0.0001783619,0.000002115684,0.1025751,5.774684e-7,0.0002518145,0.002895091],"study_design_scores_gemma":[0.004885192,0.001245063,0.6966335,0.001380377,0.0001396534,0.0001296437,0.00003069227,0.00001716825,0.295258,0.000001269894,0.0001407077,0.0001387044],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976422,0.0003641681,0.00002869199,0.000465292,0.0001002345,0.0002929545,0.00003848607,0.000008903302,0.001059026],"genre_scores_gemma":[0.9990939,0.0001550882,0.00007916973,0.0001435635,0.000414723,0.00000573041,0.000009670893,0.00003808921,0.00006002737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192683,"threshold_uncertainty_score":0.6361568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008810261783390984,"score_gpt":0.2503778863884722,"score_spread":0.2415676246050812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}