{"id":"W2331674475","doi":"10.1097/coc.0b013e3182467a13","title":"Phase I Trial of AEG35156 an Antisense Oligonucleotide to XIAP Plus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma","year":2012,"lang":"en","type":"article","venue":"American Journal of Clinical Oncology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Medicine; Gemcitabine; Pancreatic ductal adenocarcinoma; Oncology; Adenocarcinoma; Pancreatic cancer; Internal medicine; Cancer research; XIAP; Chemotherapy; Pancreatic carcinoma; Cancer; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001281969,0.0001518114,0.0009476561,0.0001253672,0.00002083145,0.000004816017,0.0001651401,0.00008833469,0.00001844911],"category_scores_gemma":[0.0004406529,0.0001106023,0.0001741304,0.0001837292,0.0002377889,0.00001850985,0.00004942566,0.0001907437,0.000002225759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003486732,"about_ca_system_score_gemma":0.0003461011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003477674,"about_ca_topic_score_gemma":0.00001760169,"domain_scores_codex":[0.9974325,0.0005625792,0.00129317,0.0001962067,0.0002284128,0.0002871065],"domain_scores_gemma":[0.9978433,0.0001488864,0.001180938,0.0002352708,0.0002236084,0.0003680306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.374112,0.02068977,0.2828418,0.00003471749,0.0009222941,0.000109821,0.0006068341,0.0004863075,0.03345365,0.0001718835,0.0002219751,0.2863489],"study_design_scores_gemma":[0.1840292,0.253739,0.5534066,0.00005678176,0.0005758806,0.0001495699,0.0005872271,0.00009788001,0.003792423,0.00004370853,0.003114057,0.000407672],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979247,0.0001089321,0.001002264,0.0001199473,0.000461108,0.0003142953,0.000008280329,0.00000190622,0.00005859597],"genre_scores_gemma":[0.9889353,0.00007720246,0.0101465,0.0002421926,0.0005333369,0.000003821075,0.00002255818,0.00002124793,0.00001785392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2859412,"threshold_uncertainty_score":0.451023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633009900065996,"score_gpt":0.3926177608916083,"score_spread":0.3562876618909483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}