{"id":"W2331678896","doi":"10.1038/onc.2015.242","title":"The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development","year":2015,"lang":"en","type":"article","venue":"Oncogene","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Agence Nationale de la Recherche; Conseil régional de Bourgogne-Franche-Comté; Ligue Contre le Cancer; Institute of Cancer Research; Institut National Du Cancer; Association pour la Recherche sur le Cancer","keywords":"XBP1; Paneth cell; Biology; Stem cell; Unfolded protein response; Ex vivo; Stromal cell; Cancer research; Immunology; In vivo; LGR5; Graft-versus-host disease; Transplantation; Cell biology; Small intestine; Endoplasmic reticulum; Cancer stem cell; Internal medicine; Endocrinology; Medicine; RNA splicing; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007418879,0.0001915969,0.0001036213,0.00002478953,0.0003613023,0.00009583676,0.0003367404,0.00009268441,0.00000293955],"category_scores_gemma":[0.0002995356,0.0001154619,0.00004117021,0.0001321967,0.0001945637,0.000004887489,0.0005829762,0.0002073884,0.00004195186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006851738,"about_ca_system_score_gemma":0.00093421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001859698,"about_ca_topic_score_gemma":0.0001026709,"domain_scores_codex":[0.9984027,0.0002007986,0.0002113855,0.0003762891,0.0003933229,0.0004155194],"domain_scores_gemma":[0.9988146,0.00005393802,0.00005653288,0.0004863655,0.0002007869,0.000387727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001542539,0.0001327251,0.001019116,0.00005759772,0.00006093069,0.00003574549,0.0003189423,0.00001255402,0.9559998,0.00002882166,0.004263028,0.03652819],"study_design_scores_gemma":[0.001076382,0.0003615728,0.0003580321,0.00002100979,0.000009001702,0.00001033011,0.0001931802,0.00002907472,0.7999042,0.00001114239,0.197859,0.0001671326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918929,0.004765725,0.0001590561,0.001021714,0.000156579,0.0008638432,0.000007412445,0.00001655187,0.001116227],"genre_scores_gemma":[0.996623,0.0001176504,0.0004019327,0.00009006985,0.0002808172,0.000284515,0.00002010148,0.00003160182,0.002150287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1935959,"threshold_uncertainty_score":0.4708399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591983016557227,"score_gpt":0.2831277637193865,"score_spread":0.2472079335538143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}