{"id":"W2331679660","doi":"10.1158/1538-7445.am2013-lb-92","title":"Abstract LB-92: RVX-2135 is a novel, orally bioavailable epigenetic BET inhibitor that synergizes with cytarabine and idarubicin to inhibit proliferation of acute myeloid leukemia cells.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Bromodomain; Cytarabine; BRD4; Idarubicin; BET inhibitor; Cancer research; Biology; Molecular biology; Acetylation; Chemistry; Myeloid leukemia; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006528248,0.0003539194,0.0002228122,0.0001692833,0.00007883367,0.0001879855,0.0002515453,0.0001849185,0.001634561],"category_scores_gemma":[0.00003147161,0.00008994655,0.000204143,0.000149626,0.0001031371,0.00009449731,0.0001099234,0.0004233037,0.0006104733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002662029,"about_ca_system_score_gemma":0.0001363334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005061725,"about_ca_topic_score_gemma":0.0007579709,"domain_scores_codex":[0.9999567,0.000006170052,0.000003522016,0.000008693006,0.00001314543,0.0000116724],"domain_scores_gemma":[0.9999866,0.000001221237,0.000004438672,0.000001315234,0.000001449795,0.000004964387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003390276,0.0001225873,0.0002838479,0.00007957513,0.00001324774,0.00007253272,0.000006946622,0.0001813051,0.9901937,0.0001789706,0.0002735157,0.008254702],"study_design_scores_gemma":[0.000227981,0.002371243,0.004039069,0.00001216945,0.00006987666,0.001049439,0.0000111266,0.0009286771,0.9767066,0.00003636781,0.01454094,0.000006565328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792269,0.00897509,0.004215153,0.0001944452,0.0001040189,0.0001253253,0.001185407,0.0003778614,0.005595876],"genre_scores_gemma":[0.9883409,0.002327297,0.002009942,0.00007845068,0.00001712249,0.00005397181,0.002102892,0.00001257213,0.005056785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001634561,"threshold_uncertainty_score":0.00546819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02650729316815758,"score_gpt":0.3010008548281426,"score_spread":0.2744935616599851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}