{"id":"W2331682375","doi":"10.1021/ol1018147","title":"Stereocontrolled Synthesis of Contiguous C(sp<sup>3</sup>)−C(aryl) Bonds by Lanthanide(III)-Catalyzed Domino Aryl-Claisen [3,3]-Sigmatropic Rearrangements","year":2010,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Aryl; Sigmatropic reaction; Stereospecificity; Catalysis; Domino; Claisen rearrangement; Medicinal chemistry; Cascade reaction; Stereochemistry; Yield (engineering); Organic chemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335227,0.0004799762,0.0002264959,0.0001840882,0.0001678109,0.0003210503,0.0004611896,0.0002200029,0.001808026],"category_scores_gemma":[0.0001574998,0.0002065956,0.0001865528,0.0002838983,0.0002314612,0.0002762806,0.0003901703,0.0004179633,0.000808928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294616,"about_ca_system_score_gemma":0.0003937698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743125,"about_ca_topic_score_gemma":0.001480668,"domain_scores_codex":[0.9999064,0.00000915284,0.000009265307,0.00002152265,0.00001762285,0.00003598018],"domain_scores_gemma":[0.9999163,0.00001130563,0.00002651898,0.00001177234,0.00001470918,0.00001945641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006956103,0.00002242063,0.000123067,0.0000782842,0.000008558041,0.0002197239,0.00006021131,0.0002873003,0.9886297,0.001829777,0.0002318141,0.008439585],"study_design_scores_gemma":[0.00001721964,0.0001157474,0.000339287,0.000004381339,0.00001103985,0.000208353,0.00001944631,0.0005067043,0.9926549,0.0001924214,0.005919989,0.00001059088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626721,0.001355016,0.01747606,0.0001088257,0.00007739419,0.00009518857,0.0006515525,0.0003259483,0.01723797],"genre_scores_gemma":[0.9805518,0.001294971,0.01324744,0.0000658379,0.00001545801,0.00006746955,0.0003848432,0.00007589331,0.004296357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808026,"threshold_uncertainty_score":0.006048441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007516585418939375,"score_gpt":0.2258520949769621,"score_spread":0.2183355095580228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}