{"id":"W2331705019","doi":"10.1042/bcj20160249","title":"Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor","year":2016,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Liver physiology and pathology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"GRB2; SH2 domain; Signal transducing adaptor protein; Phosphotyrosine-binding domain; Proto-oncogene tyrosine-protein kinase Src; Cell biology; Biology; Receptor tyrosine kinase; Gene isoform; HEK 293 cells; Immunoprecipitation; Tyrosine kinase; Tyrosine; Protein–protein interaction; Receptor; SH3 domain; Phosphorylation; Signal transduction; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796869,0.0003540014,0.0001573644,0.0002278723,0.0002827853,0.0004066072,0.0003304919,0.0003064063,0.001876529],"category_scores_gemma":[0.0002088757,0.0001805905,0.0002624629,0.0001720227,0.0002357711,0.0004269734,0.0005109485,0.0004586446,0.0006916124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000321519,"about_ca_system_score_gemma":0.0001477421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002742269,"about_ca_topic_score_gemma":0.0003895413,"domain_scores_codex":[0.9996636,0.00004668005,0.00001593505,0.00007148975,0.0001087487,0.00009347187],"domain_scores_gemma":[0.9998796,0.00001738501,0.00003768383,0.00001765922,0.00001833563,0.00002933392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169504,0.00003483797,0.001044028,0.0001033701,0.00001536897,0.0005168315,0.00004320367,0.0001057151,0.9940632,0.001115208,0.000143971,0.002644764],"study_design_scores_gemma":[0.00007629897,0.0003558373,0.07337534,0.00003652105,0.00004917651,0.004225709,0.0002422294,0.008908051,0.8995896,0.001370578,0.01173845,0.00003219126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821612,0.00764876,0.007071785,0.0002314732,0.00004564642,0.00003397467,0.0002141827,0.0000965397,0.002496404],"genre_scores_gemma":[0.995188,0.001573221,0.001124211,0.00003646477,0.00002561056,0.00003144791,0.000248291,0.000006704324,0.001766059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001876529,"threshold_uncertainty_score":0.006277621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401746416143066,"score_gpt":0.2826147746476451,"score_spread":0.2685973104862144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}