{"id":"W2331712062","doi":"10.1021/bi400187w","title":"Loop Sequence Dictates the Secondary Structure of a Human Membrane Protein Hairpin","year":2013,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"POPC; Circular dichroism; Transmembrane protein; Chemistry; Biophysics; Membrane; Vesicle; Transmembrane domain; Bacterial outer membrane; Lipid bilayer; Membrane protein; Protein structure; Protein secondary structure; Crystallography; Biochemistry; Biology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546063,0.000208235,0.0001562187,0.0001023397,0.0001487165,0.0002436713,0.0001072356,0.0002664804,0.0009115418],"category_scores_gemma":[0.0003127768,0.00009963135,0.000197163,0.00006651128,0.0001527675,0.0001323313,0.0001277916,0.000282449,0.0005012534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000168493,"about_ca_system_score_gemma":0.0001795706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002667974,"about_ca_topic_score_gemma":0.0003030783,"domain_scores_codex":[0.9999,0.0000227434,0.000007136287,0.0000280082,0.00002058076,0.00002151315],"domain_scores_gemma":[0.9997934,0.00006651717,0.00004551556,0.00001591208,0.00002982297,0.00004886899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006928286,0.00001097304,0.0004605805,0.00001009658,0.000003340269,0.00009811769,0.00001468812,0.0001562458,0.9983569,0.0001194097,0.00002084493,0.0006794836],"study_design_scores_gemma":[0.00002631753,0.0009269008,0.009786295,0.00001030706,0.0000324165,0.001018486,0.0000383507,0.003410307,0.9822707,0.0002974423,0.002166655,0.00001577236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964069,0.0002499222,0.00256861,0.00003340346,0.00001682967,0.00002677141,0.00008109371,0.00006138771,0.0005551773],"genre_scores_gemma":[0.9983056,0.00007533276,0.001104146,0.00003647126,0.000008018713,0.00001055973,0.000135881,0.000007172972,0.0003169085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009115418,"threshold_uncertainty_score":0.003049374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008214000954085669,"score_gpt":0.2397575625822128,"score_spread":0.2315435616281271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}