{"id":"W2331727595","doi":"10.1080/23723556.2015.1046579","title":"PINK1 deficiency enhances autophagy and mitophagy induction","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mitophagy; PINK1; Autophagy; Mitochondrion; Cell biology; Biology; Programmed cell death; PTEN; Downregulation and upregulation; Genetics; Gene; Apoptosis; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543275,0.0003470555,0.0004462626,0.0003412558,0.0001604005,0.0003844368,0.0001577177,0.0002882481,0.001056517],"category_scores_gemma":[0.0001466757,0.0001496873,0.0002440149,0.0002396042,0.0002629498,0.0003203444,0.0003785237,0.000525534,0.0002613879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742303,"about_ca_system_score_gemma":0.0002740413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005200296,"about_ca_topic_score_gemma":0.0006430911,"domain_scores_codex":[0.9998337,0.00003207286,0.0000194541,0.00003012599,0.00003133689,0.00005325193],"domain_scores_gemma":[0.99985,0.0000260546,0.00003913064,0.00001612158,0.0000143994,0.00005430462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007549981,0.00008743985,0.0002249985,0.0001008582,0.00001058582,0.0001479323,0.00003983826,0.0001124178,0.9966624,0.0001895645,0.00008106121,0.001588012],"study_design_scores_gemma":[0.00004784547,0.0009905249,0.004966164,0.00001528398,0.00003461592,0.0003532088,0.00005649107,0.0008072938,0.9898358,0.0001346343,0.002749956,0.000008226456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995817,0.001922033,0.0005959687,0.00009761463,0.00002650187,0.00001722242,0.000187991,0.00007048441,0.001265271],"genre_scores_gemma":[0.9970319,0.0009738854,0.0004234337,0.00003640484,0.000006488573,0.00001677643,0.0001854903,0.00001123197,0.001314274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056517,"threshold_uncertainty_score":0.003534436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242317343948402,"score_gpt":0.3062391245532559,"score_spread":0.2820073901584156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}