{"id":"W2331727595","doi":"10.1080/23723556.2015.1046579","title":"PINK1 deficiency enhances autophagy and mitophagy induction","year":2015,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mitophagy; PINK1; Autophagy; Mitochondrion; Cell biology; Biology; Programmed cell death; PTEN; Downregulation and upregulation; Genetics; Gene; Apoptosis; PI3K/AKT/mTOR pathway; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002730086,0.0002046692,0.0003815193,0.0001431376,0.00007311336,0.00001764423,0.0001054114,0.000262765,0.0001041915],"category_scores_gemma":[0.0000820651,0.0001880403,0.00009683993,0.0002170887,0.0002122111,0.0000755709,0.000062987,0.0002341245,0.0001225994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001426522,"about_ca_system_score_gemma":0.0004019755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003809925,"about_ca_topic_score_gemma":0.000002680838,"domain_scores_codex":[0.998523,0.000152267,0.0002777477,0.0004192848,0.0002809331,0.0003467608],"domain_scores_gemma":[0.9990747,0.00002555574,0.0001043194,0.0003328299,0.0001245656,0.0003380333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002619522,0.0004260374,0.000303087,0.00003912522,0.0000792249,0.001652466,0.0004873316,0.000007533113,0.9733937,0.001639837,0.0005163802,0.02119328],"study_design_scores_gemma":[0.002507988,0.001950909,0.001241772,0.0000183453,0.0001416123,0.0003828395,0.0002747993,0.0001508041,0.9486242,0.0027427,0.04174866,0.0002153915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970058,0.01486948,0.004802354,0.0006253353,0.0005502172,0.0003351402,0.000001794626,0.0001068423,0.008650827],"genre_scores_gemma":[0.9955822,0.0001322059,0.001706353,0.001717337,0.0002097965,0.00003919757,0.00002788162,0.00003220779,0.0005528542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04123228,"threshold_uncertainty_score":0.7668061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242317343948402,"score_gpt":0.3062391245532559,"score_spread":0.2820073901584156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}