{"id":"W2331757943","doi":"10.3899/jrheum.141070","title":"Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts","year":2015,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Bosentan; Myofibroblast; Fibronectin; Medicine; Fibroblast; Blot; Extracellular matrix; Immunocytochemistry; Molecular biology; Endocrinology; Pathology; Internal medicine; Endothelin receptor; Pharmacology; Receptor; In vitro; Biology; Fibrosis; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002394365,0.0003022769,0.0003090736,0.0001466058,0.0001408064,0.0001981311,0.0001271047,0.0002194374,0.001685739],"category_scores_gemma":[0.0001250306,0.00008462943,0.0003105471,0.0001426199,0.0001268128,0.0001119898,0.0000933039,0.0002635274,0.0003799729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399677,"about_ca_system_score_gemma":0.0001500502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008301934,"about_ca_topic_score_gemma":0.00109905,"domain_scores_codex":[0.9997742,0.00006628236,0.00003257469,0.00004646606,0.00004893861,0.00003161887],"domain_scores_gemma":[0.9999002,0.00002877354,0.00001522915,0.00001525107,0.00002532038,0.00001520159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001041833,0.0002378437,0.0003933435,0.0001217875,0.00001355981,0.0001333184,0.00004267504,0.00008669098,0.9947659,0.00002888673,0.00005193377,0.003082172],"study_design_scores_gemma":[0.00008052978,0.003897207,0.007176337,0.00001291561,0.00004619649,0.0003213987,0.00008803703,0.0004920253,0.9859588,0.00001529115,0.001904319,0.000007001398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929777,0.004338341,0.0006220058,0.00004988701,0.00005312299,0.00004279002,0.0003514627,0.00001936436,0.001545252],"genre_scores_gemma":[0.9943083,0.00174752,0.001186617,0.00005232215,0.00002601857,0.00008469001,0.0006096533,0.0000056607,0.001979234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001685739,"threshold_uncertainty_score":0.005639374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645948844097138,"score_gpt":0.2490725674603216,"score_spread":0.2326130790193502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}