{"id":"W2331763687","doi":"10.1371/journal.pone.0060804","title":"DIDS (4,4-Diisothiocyanatostilbenedisulphonic Acid) Induces Apoptotic Cell Death in a Hippocampal Neuronal Cell Line and Is Not Neuroprotective against Ischemic Stress","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institutes of Health; National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; University of California, San Diego","keywords":"DIDS; Apoptosis; Cell biology; Biology; Neuroprotection; Viability assay; Programmed cell death; Molecular biology; Fragmentation (computing); Chemistry; Biochemistry; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005166655,0.000237667,0.0002083343,0.00008292824,0.00006096221,0.00005670681,0.0001729292,0.0001664087,0.00005752779],"category_scores_gemma":[0.00006909311,0.0002361298,0.00005760401,0.0001152882,0.00007222718,0.00001743325,0.0001540567,0.0002044847,0.00003518972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001623729,"about_ca_system_score_gemma":0.00008219173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004212308,"about_ca_topic_score_gemma":0.000008253595,"domain_scores_codex":[0.9986314,0.00006673032,0.0002461956,0.0005129873,0.0002333065,0.0003094379],"domain_scores_gemma":[0.9992598,0.00001701101,0.00009913755,0.0003070068,0.00009648871,0.0002205115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009282649,0.0008157801,0.008875825,0.0000910819,0.00002553127,0.000004016468,0.00007145664,0.00002601914,0.9895217,0.000002176942,0.000107236,0.0003663492],"study_design_scores_gemma":[0.001182238,0.0002305685,0.04212946,0.00003371434,0.00003575491,8.048855e-7,0.00005271683,0.001295297,0.9547283,0.00002600255,0.00003148027,0.0002536521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975801,0.0006733927,0.00002548443,0.000300724,0.00002567033,0.0004761092,0.00005324312,0.00002018982,0.0008451026],"genre_scores_gemma":[0.9975166,0.0002537089,0.0003413867,0.001137632,0.0001211708,0.00008236001,0.00008437763,0.00003772496,0.0004250722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03479339,"threshold_uncertainty_score":0.9629092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757783481065982,"score_gpt":0.211291174054884,"score_spread":0.1937133392442242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}