{"id":"W2331785021","doi":"10.1021/jm2017336","title":"Design, Synthesis, and Preliminary Biological Evaluation of 6-<i>O</i>-Glucose–Azomycin Adducts for Diagnosis and Therapy of Hypoxic Tumors","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada); University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; In vivo; In vitro; Glucose transporter; Hypoxia (environmental); Pharmacology; Glucose uptake; Downregulation and upregulation; Toxicity; Limiting; Cancer research; Biochemistry; Oxygen; Insulin; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000406576,0.0004706669,0.0002620681,0.0002597465,0.0002822657,0.0002779909,0.0004137862,0.0004423165,0.0009628958],"category_scores_gemma":[0.0003198802,0.0002118656,0.0002461098,0.0004005261,0.0002079719,0.0002864146,0.000158505,0.0004102722,0.0004542363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003898188,"about_ca_system_score_gemma":0.0005767395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180621,"about_ca_topic_score_gemma":0.001583808,"domain_scores_codex":[0.9998195,0.00004818846,0.00001629587,0.00003530734,0.00004669031,0.00003396449],"domain_scores_gemma":[0.9998161,0.0000225101,0.0000472526,0.00002092528,0.0000422372,0.00005107388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002059296,0.0001194865,0.0002050437,0.000109851,0.00001474093,0.00008873723,0.00005770449,0.001598682,0.9897665,0.0003913786,0.00008046084,0.007361491],"study_design_scores_gemma":[0.00003463482,0.0009734268,0.0005199715,0.000003973831,0.00001588052,0.00009648254,0.000008358373,0.0005082685,0.9949296,0.00003666037,0.002865447,0.000007380425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9409541,0.002259516,0.04921078,0.0001938176,0.00004956606,0.001261363,0.0009809857,0.0001849592,0.004904891],"genre_scores_gemma":[0.9481911,0.002499509,0.04377261,0.00007994664,0.00001849201,0.0003384711,0.001587522,0.00006532196,0.003446908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180621,"threshold_uncertainty_score":0.003221154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05464544933995576,"score_gpt":0.3038339087467487,"score_spread":0.2491884594067929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}