{"id":"W2331785021","doi":"10.1021/jm2017336","title":"Design, Synthesis, and Preliminary Biological Evaluation of 6-<i>O</i>-Glucose–Azomycin Adducts for Diagnosis and Therapy of Hypoxic Tumors","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada); University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; In vivo; In vitro; Glucose transporter; Hypoxia (environmental); Pharmacology; Glucose uptake; Downregulation and upregulation; Toxicity; Limiting; Cancer research; Biochemistry; Oxygen; Insulin; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001828477,0.0001340841,0.0003524315,0.00003230988,0.00002743408,0.000003236605,0.0001074874,0.0001492523,0.00002857821],"category_scores_gemma":[0.0009076918,0.00009912501,0.00008526549,0.00004137357,0.0001781754,0.000009550381,0.00003064274,0.00009096638,4.402385e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001091349,"about_ca_system_score_gemma":0.0001575208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002554071,"about_ca_topic_score_gemma":1.193781e-7,"domain_scores_codex":[0.9989016,0.00009657737,0.0004129179,0.0001314664,0.0002903183,0.0001671337],"domain_scores_gemma":[0.9987347,0.0001888715,0.0004769743,0.0001228879,0.0003375219,0.0001390651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009220749,0.0001501781,0.002989469,0.0001141516,0.00009838815,3.65514e-7,0.00009874335,0.000006425722,0.9472497,0.000001223374,0.0007976755,0.04757158],"study_design_scores_gemma":[0.001552217,0.0007241165,0.008918109,0.0001397987,0.0001852468,0.0002079309,0.0002255835,0.0000165599,0.984836,0.00006281229,0.003033186,0.00009841623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8559234,0.1434123,0.000219719,0.00008201334,0.0001538003,0.0001668007,0.00001121062,0.000001057159,0.0000297316],"genre_scores_gemma":[0.9668966,0.03069302,0.001109326,0.00004087266,0.001204677,0.00003165214,0.000005860479,0.00001066504,0.000007323174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1127192,"threshold_uncertainty_score":0.4042201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05464544933995576,"score_gpt":0.3038339087467487,"score_spread":0.2491884594067929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}