{"id":"W2331846333","doi":"10.1021/acschembio.5b00839","title":"A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Novartis Pharma; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; American Cancer Society; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Wellcome; European Commission; Pfizer","keywords":"Arginine; Methyltransferase; Lysine; Biochemistry; Protein arginine methyltransferase 5; Methylation; Enzyme; Transferase; Chemistry; Biology; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724761,0.0005036521,0.0003082934,0.0002147071,0.0001430464,0.0002233352,0.000365941,0.0002795665,0.0006640684],"category_scores_gemma":[0.00009573499,0.0001394054,0.000279996,0.0002226948,0.0001544046,0.0001396648,0.0001663069,0.000604169,0.0003311851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003234818,"about_ca_system_score_gemma":0.0003410077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008766326,"about_ca_topic_score_gemma":0.001855959,"domain_scores_codex":[0.9998642,0.00001974384,0.00001587486,0.00002708895,0.00004883965,0.00002424452],"domain_scores_gemma":[0.9999455,0.00001066899,0.00001264156,0.000006126044,0.000008346235,0.00001664838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001875433,0.0001014248,0.0002504703,0.00004985399,0.00001185312,0.00004200526,0.00000928934,0.0002106152,0.9941286,0.00008825676,0.0001575659,0.004762503],"study_design_scores_gemma":[0.00008841798,0.0008222691,0.001248058,0.000002492625,0.00001654206,0.0002853683,0.00000590174,0.000685355,0.9925368,0.00001729692,0.004285738,0.000005814471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9638141,0.01313913,0.01554892,0.0003051774,0.0001121129,0.0002392306,0.001576034,0.0004023714,0.004863],"genre_scores_gemma":[0.9736907,0.006847492,0.01001013,0.0001616154,0.00003859427,0.0001482161,0.002962127,0.00002794825,0.006113257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008766326,"threshold_uncertainty_score":0.002346992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382635830784914,"score_gpt":0.2663526206907353,"score_spread":0.2525262623828862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}