{"id":"W2331846333","doi":"10.1021/acschembio.5b00839","title":"A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases","year":2015,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; National Institute of General Medical Sciences; Novartis Pharma; National Institutes of Health; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Ontario Ministry of Economic Development and Innovation; American Cancer Society; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Wellcome; European Commission; Pfizer","keywords":"Arginine; Methyltransferase; Lysine; Biochemistry; Protein arginine methyltransferase 5; Methylation; Enzyme; Transferase; Chemistry; Biology; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007870523,0.000124227,0.0001805065,0.00003345333,0.00001918638,0.000002918252,0.00008028858,0.0002781638,0.000005310125],"category_scores_gemma":[0.0001388521,0.0001148733,0.0000342215,0.0001116651,0.000176924,0.000002869619,0.00006358195,0.00009750955,0.00000179097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002126016,"about_ca_system_score_gemma":0.00007652723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003992876,"about_ca_topic_score_gemma":0.000007848004,"domain_scores_codex":[0.9992539,0.00005747046,0.0001738114,0.0003032471,0.00005147428,0.0001600827],"domain_scores_gemma":[0.9994745,0.00001116999,0.0001155652,0.0001512406,0.0001662033,0.0000813115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003097828,0.00005378751,0.0005036363,0.00001315688,0.00004366883,2.95966e-7,0.00004142373,0.000002595127,0.99734,0.00005013454,0.0003805704,0.001260982],"study_design_scores_gemma":[0.0008684741,0.0008111111,0.0001836947,0.00000806598,0.00001980581,0.000006244625,0.00002658874,0.00000456258,0.9958242,0.0003778448,0.001741673,0.000127743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979652,0.001043475,0.00007616555,0.00009413934,0.00005026728,0.0002144266,0.00002289578,0.00001049917,0.0005229479],"genre_scores_gemma":[0.9990293,0.00004634558,0.000313501,0.00003065355,0.0001753252,0.00001917613,0.0002747967,0.00001410721,0.00009678747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515774,"threshold_uncertainty_score":0.4684399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382635830784914,"score_gpt":0.2663526206907353,"score_spread":0.2525262623828862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}