{"id":"W2331853981","doi":"10.1021/bc4004662","title":"PESIN Multimerization Improves Receptor Avidities and <i>in Vivo</i> Tumor Targeting Properties to GRPR-Overexpressing Tumors","year":2014,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Bundesministerium für Bildung und Forschung","keywords":"Avidity; Chemistry; Peptide; In vivo; Receptor; Monomer; In vitro; Biophysics; Cancer research; Stereochemistry; Biochemistry; Antigen; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462903,0.000202928,0.0002545169,0.00002126053,0.0001122546,0.00005561761,0.00008705964,0.00007996928,0.0001235955],"category_scores_gemma":[0.0002794366,0.0001849111,0.00003922703,0.0001430349,0.0001407203,0.00008801051,0.00005508137,0.0001826382,0.00001252439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005448142,"about_ca_system_score_gemma":0.00004512509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001345363,"about_ca_topic_score_gemma":1.206414e-7,"domain_scores_codex":[0.9988433,0.00001636627,0.0003157837,0.0003995571,0.0001413165,0.0002837131],"domain_scores_gemma":[0.9993824,0.00004058128,0.00007948399,0.0001994503,0.00005423679,0.0002438678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001113396,0.00005740176,0.0004781556,0.0006859564,0.00000663367,0.000002255164,0.0001460938,0.00001101486,0.9973614,0.00000632099,0.0006850017,0.0004484428],"study_design_scores_gemma":[0.000623599,0.00001878162,0.0001691275,0.0003193891,0.00001986415,0.0000191881,0.0002799302,0.001806881,0.9837287,0.00001447654,0.01277761,0.0002224759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957444,0.0003180578,0.000107855,0.0008973195,0.00002536654,0.0003175857,0.00001895899,0.00009380603,0.002476635],"genre_scores_gemma":[0.9958848,0.00001868112,0.00178867,0.0005506748,0.0003322542,0.0001196392,0.00003388595,0.00002957511,0.001241821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01363271,"threshold_uncertainty_score":0.7540455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441918049186448,"score_gpt":0.2507768313438477,"score_spread":0.2363576508519832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}