{"id":"W2331853981","doi":"10.1021/bc4004662","title":"PESIN Multimerization Improves Receptor Avidities and <i>in Vivo</i> Tumor Targeting Properties to GRPR-Overexpressing Tumors","year":2014,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Bundesministerium für Bildung und Forschung","keywords":"Avidity; Chemistry; Peptide; In vivo; Receptor; Monomer; In vitro; Biophysics; Cancer research; Stereochemistry; Biochemistry; Antigen; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152118,0.0003731605,0.0002127315,0.0001272868,0.00006934545,0.0002115563,0.0001545821,0.0002454926,0.0009077413],"category_scores_gemma":[0.0001212198,0.000105923,0.0001326088,0.0000952067,0.00011255,0.0002194954,0.0001689426,0.0003661861,0.0002519659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002430509,"about_ca_system_score_gemma":0.00008776398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002465909,"about_ca_topic_score_gemma":0.000353597,"domain_scores_codex":[0.999916,0.00001156692,0.00000760588,0.0000272148,0.00001690747,0.00002065016],"domain_scores_gemma":[0.9999104,0.00001541561,0.00003470373,0.000008484383,0.00001038517,0.00002069323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003098522,0.00001094392,0.00004526085,0.000008652794,0.00000212596,0.000008772199,0.000004140948,0.0001009689,0.9991315,0.00001707901,0.00001190277,0.0006276735],"study_design_scores_gemma":[0.000004924671,0.0001483644,0.0007197874,0.000001146917,0.000007646388,0.00004762736,0.000004789521,0.0006410719,0.9977837,0.00000647142,0.0006325232,0.00000210049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995486,0.0003797923,0.003241945,0.0000408249,0.00000907408,0.00001343571,0.00005497647,0.0000824629,0.0006916185],"genre_scores_gemma":[0.9945107,0.0003220257,0.003240907,0.00003798139,0.000005238675,0.00001311421,0.0000975431,0.00003608782,0.001736408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009077413,"threshold_uncertainty_score":0.003036737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01441918049186448,"score_gpt":0.2507768313438477,"score_spread":0.2363576508519832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}