{"id":"W2331899671","doi":"10.1021/jm301678j","title":"Antimalarial Activities of 6-Iodouridine and Its Prodrugs and Potential for Combination Therapy","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General & Western Hospital Foundation; Canada Research Chairs; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Plasmodium chabaudi; Prodrug; Pharmacology; Combination therapy; Chemistry; Plasmodium falciparum; Artemisinin; Malaria; Context (archaeology); Drug; Drug resistance; In vivo; Azithromycin; Antibiotics; Biochemistry; Microbiology; Medicine; Parasitemia; Immunology; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002906146,0.0004019833,0.0006137781,0.0004513573,0.000124449,0.0002975848,0.0004026395,0.000391,0.001788119],"category_scores_gemma":[0.0001359373,0.0001544417,0.0002744058,0.0003093262,0.0001979364,0.0003637874,0.0002899819,0.0004815639,0.0004346038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002284021,"about_ca_system_score_gemma":0.0001298269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001678421,"about_ca_topic_score_gemma":0.0005005622,"domain_scores_codex":[0.9998851,0.00003698724,0.00001123304,0.00001781773,0.00002564381,0.00002329984],"domain_scores_gemma":[0.9999567,0.000008294125,0.0000100797,0.000006274596,0.000006195536,0.00001236744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002041896,0.0007793837,0.000813377,0.0008151346,0.00009248492,0.001318837,0.0001015326,0.00224677,0.7998518,0.004045162,0.001110886,0.1867827],"study_design_scores_gemma":[0.001204752,0.02627338,0.005390435,0.0001372903,0.0002898953,0.009426793,0.00009053968,0.006885997,0.8396816,0.002049384,0.1084962,0.00007379598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8154233,0.1296163,0.0231878,0.0009892422,0.0003827449,0.0004796797,0.0005537267,0.0003196306,0.02904755],"genre_scores_gemma":[0.9521533,0.0291114,0.01163965,0.0001992441,0.0001540163,0.0001099183,0.0004273958,0.00002069559,0.006184312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788119,"threshold_uncertainty_score":0.005981803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119616087638558,"score_gpt":0.2697141772693044,"score_spread":0.2585180163929188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}