{"id":"W2331918424","doi":"10.1021/bi101281f","title":"Transmembrane Helix I and Periplasmic Loop 1 of <i>Escherichia coli</i> ProP Are Involved in Osmosensing and Osmoprotectant Transport","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Periplasmic space; Symporter; Transmembrane domain; Biochemistry; Major facilitator superfamily; Transmembrane protein; Chemistry; Osmoprotectant; Escherichia coli; Biology; Biophysics; Amino acid; Mutant; Transporter; Proline; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169442,0.0001813486,0.0002076505,0.00002375677,0.00004001219,0.000009542886,0.00006882977,0.0003276604,0.000007573765],"category_scores_gemma":[0.00003256265,0.0001748357,0.00004271553,0.00009001427,0.0001894678,0.000004474603,0.00002112772,0.0002186444,2.154131e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005489889,"about_ca_system_score_gemma":0.00007192746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002997193,"about_ca_topic_score_gemma":0.0001156851,"domain_scores_codex":[0.999096,0.00001321903,0.0002331703,0.0003767108,0.00009255342,0.0001882857],"domain_scores_gemma":[0.9995493,0.000005512156,0.0000825879,0.0002259588,0.0000495003,0.00008711439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001598051,0.00003029687,0.01321521,0.0002496227,0.00001541874,0.000006438529,0.00005441363,0.00000101624,0.985356,0.000002513442,0.00002629807,0.0008829986],"study_design_scores_gemma":[0.0007762322,0.00007018033,0.01223117,0.00004549475,0.00001845632,0.00003632532,0.0001272277,0.00003600518,0.9856361,0.00002001898,0.0008032615,0.0001995739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987544,0.0005500219,0.00005744712,0.00008542163,0.00008106497,0.000184295,0.00002981649,0.00001041473,0.0002471227],"genre_scores_gemma":[0.9988345,0.0001241305,0.0006643306,0.00009438793,0.00009352757,0.000009930719,0.00005245511,0.00001944399,0.0001072908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000984033,"threshold_uncertainty_score":0.7129593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004687166897816168,"score_gpt":0.1966255871620463,"score_spread":0.1919384202642301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}