{"id":"W2331918424","doi":"10.1021/bi101281f","title":"Transmembrane Helix I and Periplasmic Loop 1 of <i>Escherichia coli</i> ProP Are Involved in Osmosensing and Osmoprotectant Transport","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Hemoglobin structure and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children; University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Periplasmic space; Symporter; Transmembrane domain; Biochemistry; Major facilitator superfamily; Transmembrane protein; Chemistry; Osmoprotectant; Escherichia coli; Biology; Biophysics; Amino acid; Mutant; Transporter; Proline; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008245571,0.0004459503,0.0002108159,0.0001411538,0.0001661401,0.0002333162,0.0002486067,0.0002725891,0.0007660022],"category_scores_gemma":[0.0001623198,0.0001249087,0.0002621276,0.0001565178,0.0002004654,0.0001568465,0.000169363,0.0003590854,0.0005291972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004130796,"about_ca_system_score_gemma":0.0002031951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006004328,"about_ca_topic_score_gemma":0.0004047554,"domain_scores_codex":[0.9999146,0.00001246575,0.000004734696,0.00001990538,0.00002434064,0.00002393322],"domain_scores_gemma":[0.9998292,0.00001949484,0.00008629198,0.00001120342,0.00002190743,0.00003185622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001374141,0.00001122676,0.0004734038,0.00004991878,0.000003894564,0.0001073543,0.00001458412,0.00008403644,0.99709,0.0001171567,0.00005678857,0.001854223],"study_design_scores_gemma":[0.00003149973,0.0004658448,0.03169929,0.00003038483,0.00003540898,0.001364024,0.00007851061,0.001439733,0.955533,0.0002677651,0.009038137,0.00001635574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923835,0.001284735,0.004109415,0.0001125595,0.00002517863,0.0000421989,0.0005473768,0.0001296712,0.001365373],"genre_scores_gemma":[0.9879506,0.000925378,0.00649687,0.0001122948,0.00002143374,0.00003868818,0.002714503,0.00002674245,0.001713632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007660022,"threshold_uncertainty_score":0.0029971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004687166897816168,"score_gpt":0.1966255871620463,"score_spread":0.1919384202642301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}