{"id":"W2331954842","doi":"10.1371/journal.pone.0101155","title":"Thyroid Hormone Response Element Half-Site Organization and Its Effect on Thyroid Hormone Mediated Transcription","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada","funders":"Health Canada","keywords":"Retinoid X receptor; Luciferase; Thyroid hormone receptor; Nuclear receptor; Transcription factor; Transfection; Response element; Chemistry; Retinoic acid; Transcription (linguistics); Molecular biology; Receptor; Retinoic acid receptor; Biology; Thyroid hormone receptor beta; Gene expression; Biochemistry; Hormone receptor; Gene; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005734549,0.0002308719,0.0002275171,0.00006680508,0.0001262357,0.00004098315,0.0001348424,0.0002181593,0.00001390861],"category_scores_gemma":[0.0007296587,0.0002109648,0.00003706844,0.0001755596,0.00004381549,0.000009991497,0.00004688765,0.0001373729,0.00006110924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003095041,"about_ca_system_score_gemma":0.00003768562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002580755,"about_ca_topic_score_gemma":0.000001736869,"domain_scores_codex":[0.9984605,0.0003006959,0.0002339438,0.0004410895,0.0003091798,0.0002546487],"domain_scores_gemma":[0.9992788,0.0000635211,0.00009709051,0.0002873326,0.0001614621,0.0001117415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0012987,0.0002734842,0.0003342126,0.00006810921,0.00009833155,0.000002367138,0.00007934696,0.00000577818,0.9973019,0.00004310385,0.0002861821,0.0002084946],"study_design_scores_gemma":[0.001787207,0.004954339,0.002056194,0.00003294675,0.0001159263,0.000005271627,0.000009361779,0.0003128479,0.9897026,0.00001856748,0.0007475217,0.0002571568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994354,0.003884863,0.0006776598,0.0002545753,0.00002808182,0.000374252,0.00001605293,0.00005125507,0.000359313],"genre_scores_gemma":[0.9960929,0.002194223,0.0001490172,0.0002486325,0.0002083935,0.0000373947,0.000554524,0.00004935123,0.0004655734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00759923,"threshold_uncertainty_score":0.8602894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008195602892668529,"score_gpt":0.199375204150037,"score_spread":0.1911796012573684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}