{"id":"W2331962380","doi":"10.1158/1538-7445.am2013-4952","title":"Abstract 4952: A novel smoothened antagonist, TAK-441, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"","keywords":"Smoothened; LNCaP; Cyclopamine; Paracrine signalling; GLI1; Prostate cancer; Cancer research; Hedgehog signaling pathway; Internal medicine; Biology; Endocrinology; Androgen receptor; Hedgehog; Sonic hedgehog; Medicine; Cancer; Signal transduction; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444814,0.0005981862,0.0005403074,0.0003258314,0.0002391584,0.0002898824,0.0004628131,0.0003752044,0.002720167],"category_scores_gemma":[0.0001138345,0.0002582843,0.000381146,0.0001786741,0.0002510718,0.0002700113,0.0001681975,0.001038908,0.000632629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244587,"about_ca_system_score_gemma":0.0004767987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005503944,"about_ca_topic_score_gemma":0.001500851,"domain_scores_codex":[0.9998916,0.00001846462,0.00001183357,0.00001572101,0.0000217532,0.00004070319],"domain_scores_gemma":[0.9999324,0.000008498093,0.00001725039,0.000006208752,0.000004596667,0.00003094185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001876782,0.0007138498,0.0003136569,0.0002403465,0.00004858524,0.0001232911,0.0000283644,0.0003676209,0.9860086,0.0002025961,0.0003940056,0.009682301],"study_design_scores_gemma":[0.001050564,0.01977323,0.009298767,0.00002863401,0.0001711488,0.0009285761,0.00007325036,0.002975958,0.9606668,0.0000866308,0.004911919,0.00003451799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930516,0.002783475,0.0008803257,0.0002508225,0.0001431249,0.00009318967,0.0005311745,0.0002236018,0.002042667],"genre_scores_gemma":[0.994044,0.001778705,0.001241051,0.0001025461,0.00003686555,0.00008572348,0.000785587,0.00001673384,0.001908735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002720167,"threshold_uncertainty_score":0.009099901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07902332384076281,"score_gpt":0.4364564706676511,"score_spread":0.3574331468268883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}