{"id":"W2331978332","doi":"10.1158/1538-7445.am2013-3265","title":"Abstract 3265: PI3Kδ inhibitor, GS-1101, impacts transcription and translation in mantle cell lymphoma.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gilead Sciences (Canada)","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Mantle cell lymphoma; Cancer research; Cell cycle; Cyclin D1; Biology; Cell biology; Apoptosis; Chemistry; Molecular biology; Signal transduction; Lymphoma; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001513161,0.0003476128,0.0002620264,0.0003384242,0.000173928,0.0002650907,0.0002658653,0.0003721327,0.002308007],"category_scores_gemma":[0.0001024395,0.0001394725,0.0002638645,0.0003071829,0.0002333654,0.0001898926,0.0001373799,0.0009117607,0.0005183474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004226549,"about_ca_system_score_gemma":0.0005212083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002051169,"about_ca_topic_score_gemma":0.002689215,"domain_scores_codex":[0.9999059,0.00001419436,0.0000101006,0.00001581287,0.00002478885,0.0000291523],"domain_scores_gemma":[0.9999609,0.000005323151,0.000007375747,0.000003369349,0.000003031869,0.00002003084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003458778,0.001282453,0.0007947879,0.0002482497,0.00003476195,0.0002040622,0.00004834921,0.0003216097,0.9808629,0.0003709864,0.00143948,0.01093368],"study_design_scores_gemma":[0.001454971,0.01736263,0.02014205,0.00004141062,0.0001786505,0.0007436372,0.0001934976,0.002326343,0.9428436,0.0002104785,0.0144831,0.00001966763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989693,0.004304088,0.0003888851,0.0004801371,0.0001689322,0.00008993089,0.001252299,0.0001895684,0.003433066],"genre_scores_gemma":[0.9922543,0.001731455,0.0005716116,0.0002744385,0.00001963386,0.00007067184,0.001628552,0.00001197706,0.003437429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002308007,"threshold_uncertainty_score":0.007721066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07073239549172139,"score_gpt":0.3697103073641917,"score_spread":0.2989779118724704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}