{"id":"W2332018270","doi":"10.1021/pr2000072","title":"Quantitative Proteomic Analysis of PCSK9 Gain of Function in Human Hepatic HuH7 Cells","year":2011,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Université de Montréal; Montreal Clinical Research Institute; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Stable isotope labeling by amino acids in cell culture; Kexin; PCSK9; Proprotein convertase; LDL receptor; Biology; Cell biology; Lipoprotein; Molecular biology; Proteomics; Biochemistry; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01020145,0.0001136368,0.001010966,0.002682833,0.00005309104,0.000007052372,0.000189329,0.0001178954,0.0002560622],"category_scores_gemma":[0.0004140515,0.00008547162,0.000561226,0.002425547,0.0001867563,0.0001332166,0.00005377296,0.0008033068,0.000004923495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002055349,"about_ca_system_score_gemma":0.0005250888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001830065,"about_ca_topic_score_gemma":0.00009199614,"domain_scores_codex":[0.9958794,0.0008676543,0.001095993,0.0001789706,0.00163735,0.0003406077],"domain_scores_gemma":[0.9973194,0.00008182897,0.0005634627,0.0004229949,0.001441346,0.0001709956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002506509,0.0009790715,0.03308824,0.001401382,0.002741826,0.0001169187,0.002459475,0.00007721055,0.9539849,0.0004129731,0.00003702165,0.002194467],"study_design_scores_gemma":[0.003274212,0.0111656,0.3427669,0.001107989,0.001109262,0.00003004146,0.001741568,0.0007887631,0.6364785,0.001368136,0.00002806252,0.0001409039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955145,0.0005003867,0.001774182,0.00007027871,0.00003430761,0.001435223,0.000004377287,0.000002939684,0.0006637847],"genre_scores_gemma":[0.9952112,0.0001242852,0.004416493,0.000006257187,0.00006878297,0.00004239995,0.000002064241,0.00001749527,0.0001109538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3175063,"threshold_uncertainty_score":0.3535639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1402291845861668,"score_gpt":0.4061235594830666,"score_spread":0.2658943748968997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}