{"id":"W2332019989","doi":"10.1136/heartjnl-2012-302920a.47","title":"RAC1 SIGNALLING MEDIATES DOXORUBICIN-INDUCED CARDIOTOXICITY THROUGH BOTH REACTIVE OXYGEN SPECIES DEPENDENT AND INDEPENDENT PATHWAYS","year":2012,"lang":"en","type":"article","venue":"Heart","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Doxorubicin; Cardiotoxicity; Reactive oxygen species; NADPH oxidase; Apoptosis; RAC1; Pharmacology; Oxidative stress; Medicine; Programmed cell death; DNA fragmentation; DNA damage; Cell biology; Biochemistry; Biology; Signal transduction; Toxicity; Endocrinology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002641472,0.0005992714,0.0003182868,0.0003064338,0.0003190582,0.0004065843,0.0002504357,0.0004437315,0.002215505],"category_scores_gemma":[0.0001421167,0.000158147,0.0004573251,0.0001457309,0.0002235417,0.0003691461,0.0002604108,0.0007146976,0.0006704214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003863331,"about_ca_system_score_gemma":0.0002273473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003231079,"about_ca_topic_score_gemma":0.0004909241,"domain_scores_codex":[0.9997622,0.00005073384,0.00001757592,0.00004584382,0.0000512537,0.00007244272],"domain_scores_gemma":[0.9998564,0.00001503233,0.00006336324,0.000009871294,0.00002624124,0.00002903189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000353472,0.0000775805,0.0006763108,0.0002512897,0.00001828927,0.0001581348,0.00004340589,0.0001859395,0.9930614,0.0004351548,0.0002539084,0.004485175],"study_design_scores_gemma":[0.0001070594,0.001125006,0.02795132,0.000106378,0.0001250293,0.001417215,0.0001451032,0.004822819,0.9459319,0.0004063832,0.01783166,0.00003017773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9626793,0.02479086,0.005954499,0.001106027,0.0001531377,0.00009413171,0.0006872875,0.0002018367,0.004332983],"genre_scores_gemma":[0.9853235,0.008050147,0.001331759,0.0001519558,0.00006346528,0.00008968058,0.000557593,0.00001354161,0.004418356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002215505,"threshold_uncertainty_score":0.007411599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04781700239169784,"score_gpt":0.274893079643947,"score_spread":0.2270760772522492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}