{"id":"W2332019989","doi":"10.1136/heartjnl-2012-302920a.47","title":"RAC1 SIGNALLING MEDIATES DOXORUBICIN-INDUCED CARDIOTOXICITY THROUGH BOTH REACTIVE OXYGEN SPECIES DEPENDENT AND INDEPENDENT PATHWAYS","year":2012,"lang":"en","type":"article","venue":"Heart","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Doxorubicin; Cardiotoxicity; Reactive oxygen species; NADPH oxidase; Apoptosis; RAC1; Pharmacology; Oxidative stress; Medicine; Programmed cell death; DNA fragmentation; DNA damage; Cell biology; Biochemistry; Biology; Signal transduction; Toxicity; Endocrinology; Internal medicine; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006820402,0.0003067813,0.0006217291,0.00009641369,0.0002174345,0.00004748768,0.0000698099,0.0002899229,0.00009705492],"category_scores_gemma":[0.000114248,0.000277587,0.0002036049,0.0001633706,0.00008499289,0.0004368368,0.00006803447,0.0005034636,0.00004288838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573785,"about_ca_system_score_gemma":0.0001153817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001548599,"about_ca_topic_score_gemma":0.00001969851,"domain_scores_codex":[0.9978361,0.0001271749,0.0003527547,0.0004152655,0.0006770788,0.0005916358],"domain_scores_gemma":[0.9989377,0.0001703882,0.0001121026,0.0003370469,0.000103882,0.0003388934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001200894,0.0001413376,0.01284387,0.00006131644,0.0001781027,0.00001794707,0.003954055,0.000002995765,0.9814742,0.0003104387,0.0002553333,0.0006403438],"study_design_scores_gemma":[0.001354568,0.0001713038,0.09236673,0.0001040753,0.0001292822,0.0002933166,0.001661348,0.00001595556,0.9001854,0.0002456923,0.003195403,0.0002768888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902716,0.001060759,0.0004371902,0.0006572029,0.0003662269,0.0007852449,0.00001833919,0.0001347733,0.006268621],"genre_scores_gemma":[0.9959007,0.000294904,0.0007877091,0.001327638,0.001331053,0.00004303942,0.00003904208,0.00005089404,0.0002250246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08128873,"threshold_uncertainty_score":0.9999676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04781700239169784,"score_gpt":0.274893079643947,"score_spread":0.2270760772522492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}