{"id":"W2332145434","doi":"10.1093/neuonc/nou278.10","title":"TM-10 * ALTERATIONS IN METABOLIC PATHWAYS IN GLIOBLASTOMA MULTIFORME CELLS IN RESPONSE TO HEXOKINASE-2 INHIBITION","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Glycolysis; Gene knockdown; Pentose phosphate pathway; Metabolic pathway; Citric acid cycle; Glioma; Hexokinase; Anaerobic glycolysis; Biology; Metabolomics; Biochemistry; Cancer research; Chemistry; Cell biology; Metabolism; Apoptosis; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001038704,0.0003782515,0.0004686451,0.0001882013,0.0001347401,0.0002625213,0.0002134825,0.0002329692,0.002712526],"category_scores_gemma":[0.00008307637,0.00009837574,0.00029203,0.0003222635,0.0001507333,0.0001308223,0.0001319648,0.0007823223,0.0005953495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003559369,"about_ca_system_score_gemma":0.0003858458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003283528,"about_ca_topic_score_gemma":0.003912225,"domain_scores_codex":[0.9998643,0.00001128325,0.00001491315,0.00002183842,0.00004007209,0.00004754369],"domain_scores_gemma":[0.999933,0.000007844921,0.000011581,0.000007007667,0.00001354382,0.00002696637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001057204,0.000362273,0.001008178,0.0001393365,0.00003759061,0.0001480472,0.0000413481,0.0002293727,0.9904074,0.0001088347,0.001338509,0.005121991],"study_design_scores_gemma":[0.00012662,0.003733046,0.02264059,0.00001726065,0.0000563647,0.0004336475,0.0001548773,0.002135992,0.9628167,0.00008152426,0.007789523,0.00001380892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923208,0.00133498,0.0009253009,0.0002816278,0.0001765495,0.0000465528,0.002501621,0.0002020421,0.002210388],"genre_scores_gemma":[0.9849156,0.001171157,0.00153282,0.0002518464,0.00001722898,0.00013702,0.006634527,0.00003218312,0.005307594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003283528,"threshold_uncertainty_score":0.009074271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110285302901276,"score_gpt":0.2598492640387753,"score_spread":0.2488207337486477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}