{"id":"W2332173011","doi":"10.1021/jm500684r","title":"Discovery of 1<i>H</i>-Indole-2-carboxamides as Novel Inhibitors of the Androgen Receptor Binding Function 3 (BF3)","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Prostate Cancer Canada; U.S. Department of Defense","keywords":"LNCaP; Enzalutamide; Androgen receptor; Chemistry; Allosteric regulation; Prostate cancer; Indole test; Function (biology); Receptor; Pharmacology; Structure–activity relationship; Androgen; Androgen Receptor Antagonists; Cancer research; Biochemistry; Cancer; In vitro; Internal medicine; Cell biology; Hormone; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001092673,0.0002712081,0.0002123044,0.0001758966,0.00009972061,0.0001771296,0.0002366608,0.0001701736,0.001028943],"category_scores_gemma":[0.00007962387,0.00008363366,0.0001896384,0.000158995,0.0001365963,0.0001508443,0.0001160934,0.000364863,0.000214092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472593,"about_ca_system_score_gemma":0.0002157222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009383722,"about_ca_topic_score_gemma":0.002331347,"domain_scores_codex":[0.9999638,0.000005629096,0.000001335469,0.000006615305,0.000007751834,0.00001489006],"domain_scores_gemma":[0.9999775,0.000003198734,0.000006031319,0.000001582881,0.000004459455,0.000007234064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000614738,0.0003369461,0.000469885,0.0002413487,0.00002422391,0.0003717197,0.00007723962,0.001790436,0.9512914,0.002088524,0.001278018,0.04141541],"study_design_scores_gemma":[0.0005995737,0.00403678,0.004724423,0.0000532359,0.0000670118,0.0008975817,0.00004330851,0.004010566,0.9517935,0.0004860054,0.03324768,0.0000403353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622365,0.0126296,0.01083503,0.0003654594,0.0001135427,0.0002916265,0.0009479404,0.0002940896,0.0122862],"genre_scores_gemma":[0.9831495,0.006827123,0.005359774,0.0002198818,0.00002905161,0.00007217501,0.0005314685,0.00001971658,0.003791288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028943,"threshold_uncertainty_score":0.003442168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532315313797408,"score_gpt":0.2724060991395719,"score_spread":0.2570829460015979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}